FB2026_02 , released June 18, 2026
Allele: Dmel\Syt1T11
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General Information
Symbol
Dmel\Syt1T11
Species
D. melanogaster
Name
FlyBase ID
FBal0032851
Feature type
allele
Associated gene
Dmel\Syt1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Littleton et al., 1994, Littleton et al., 1993)
Mutagen
ethyl methanesulfonate
(Littleton and Bellen, 1994, Littleton et al., 1994, Littleton et al., 1993)
Progenitor genotype
Cytology
Description

No obvious rearrangement as detected by Southern blot.

(Littleton et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      sytAD3/sytT11 mutants lack the on-off transients normally seen during electroretinogram recordings in the retina. The mutants do not show a depletion of synaptic vesicles at the photoreceptor synapses and synaptic vesicles can clearly be seen in contact with the presynaptic membrane under T-bars.

      (Littleton et al., 2001)

      No obvious morphological defects.

      (Littleton and Bellen, 1994)

      Transheterozygote combinations with other syt alleles are lethal.

      (Littleton et al., 1994)

      Survivors are sluggish as third instar larvae, and severely uncoordinated as adults. Most die within 48hrs of eclosion. Physiological experiments with the larval neuromuscular junction preparation reveal a striking reduction in evoked transmitter release, but no decrease in rate or amount of spontaneous transmitter release.

      (Littleton et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Isolated on basis of failure to complement Df(2L)DTD2. A few adults survive in transheterozygous combinations between sytT11, sytT77 and syt66.4. The syt alleles form a series: going from most severe to least severe, sytN19 = sytN6 >= sytT7 = sytT41 > sytT77 = syt66.4 > sytT11.

      (Littleton et al., 1993)

      Mutant phenotype can be rescued, when homozygous or in trans to sytN6, by sytelav.PD.

      (Littleton et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Syt1T11
      sytT11
      Name Synonyms
      Secondary FlyBase IDs
        References (4)