FlyBase Allele Report: Dmel\Srpk79D[P1]

General Information

Symbol

Dmel\Srpk79D^P1

Species

D. melanogaster

Name

FlyBase ID

FBal0033567

Feature type

allele

Associated gene

Dmel\Srpk79D

Associated Insertion(s)

P{lacW}Srpk79D^P1

Carried in Construct

Also Known As

csp^P2, P{lacW}Csp^P2

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Zinsmaier et al., 1994)

Progenitor genotype

Associated Insertion(s)

P{lacW}Srpk79D^P1

Cytology

Description

The P{lacW}srpk79D^P1 transposon is inserted 81 bp upstream of the first exon-intron boundary of the srpk79D RC/RF transcript and destroys the open reading frame of these mRNAs.

(Nieratschker et al., 2009)

Insertion of a P{lacW} element downstream of the Csp transcription start site. The 3' end of the P{lacW} element is closest to the Csp transcription unit.

(Eberle et al., 1998)

P-element insertion at map position +7.8.

(Zinsmaier et al., 1994)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:22,275,357..22,275,357 [+]

(Nieratschker et al., 2009, Eberle et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal flight | recessive

(Nieratschker et al., 2009)

abnormal locomotor behavior | recessive

(Nieratschker et al., 2009)

short lived | recessive

(Nieratschker et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

General axonal transport and basic synaptic structure appear intact in srpk79D^P1 mutants.

srpk79D^P1 mutant flies display flight impairment, reduced ability or motivation to walk on a horizontal surface, as well as reduced life span.

(Nieratschker et al., 2009)

Shows no reconizable mutant phenotype.

(Eberle et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Srpk79D^P1 is partially rescued by Srpk79D^RF.UAS.cNa

(Nieratschker et al., 2009)

Comments

The impaired flight, impaired walking and reduced longevity of srpk79D^P1 mutants are fully or partially rescued by transgenic pan-neural expression of srpk79D^{RF.Scer\UAS.cNa} driven by Scer\GAL4^elav-C155.

(Nieratschker et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Expression pattern of Csp is apparently normal.

(Eberle et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Csp^P2

Srpk79D^P1

(Nieratschker et al., 2009)

csp^P2

(Eberle et al., 1998, Zinsmaier et al., 1994)

srpk79D^P1

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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