FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\E(spl)m8-HLH1.tKa
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General Information
Symbol
Dmel\E(spl)m8-HLH1.tKa
Species
D. melanogaster
Name
FlyBase ID
FBal0033649
Feature type
allele
Associated gene
Dmel\E(spl)m8-HLH
Associated Insertion(s)
Carried in Construct
P{E(spl)m8-HLH1}
Key Links
Transgenic product class
inframe_deletion
(Tietze et al., 1993)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Tietze et al., 1993)
Mutagen
in vitro construct
(Tietze et al., 1993, Tietze et al., 1992, Klambt et al., 1989)
Progenitor genotype
E(spl)m8-HLH1
(Tietze et al., 1992, Klambt et al., 1989)
Carried in construct
P{E(spl)m8-HLH1}
Cytology
Description

E(spl)1 fragment carrying deletion of 483 nucleotides in the 3' translated and non-translated region, resulting in a deletion of a putative regulatory domain.

(Tietze et al., 1993)

Construct: Contained within a genomic ClaI fragment extending from map units 10.7-13.8 of FBrf0046127.

(Tietze et al., 1992)

5.1kb genomic fragment encoding E(spl)1.

(Klambt et al., 1989)
Allele components
Component
Use(s)
Encoded product / tool
E(spl)m8-HLH
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Transgene can, to some extent, rescue the neurogenic phenotype of Df(3R)E(spl)-rv27 homozygotes.

      (Tietze et al., 1993)

      Enhances Nspl-1 phenotype, as for E(spl)1.

      (Tietze et al., 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      E(spl)m8-HLH1.tKa is an enhancer of phenotype of Nspl-1

      (Tietze et al., 1993)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Protein consists of the first 123 amino acids fused in frame to an additional 9 amino acids.

      (Tietze et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      E(spl)1.tKa
      E(spl)D
      (Tietze et al., 1993)
      E(spl)m8-HLH1.tKa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)