FlyBase Allele Report: Dmel\N[su42c]

General Information

Symbol

Dmel\N^su42c

Species

D. melanogaster

Name

FlyBase ID

FBal0033873

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Brennan et al., 1997)

Mutagen

Progenitor genotype

N^Ax-9

(Diederich et al., 1994)

Cytology

Description

Point mutation in the fifth cdc10 repeat.

(Brennan et al., 1997)

Amino acid replacement: A2060V. A2060 is a conserved residue and falls in the fifth ankyrin repeat.

(Diederich et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:3,168,807..3,168,807 [+]

Nucleotide change:

C3168807T

Amino acid change:

A2060V | N-PA; A2060V | N-PB

Reported amino acid change:

A2060V

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. Author statement: A2060 is a conserved residue and falls in the fifth ankyrin repeat.

(Diederich et al., 1994)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | dominant | neurogenic phenotype

(Brennan et al., 1997)

Phenotype Manifest In

adult thoracic sensillum

(Brennan et al., 1997)

ocellus

(Diederich et al., 1994)

wing

(Diederich et al., 1994)

Detailed Description

Statement

Reference

Heterozygotes have a neurogenic phenotype and have an increase in the number of thoracic bristles compared to wild-type. The number of bristles is restored almost to wild-type in N^su42c ; Dp(1;2)51b double heterozygotes.

(Brennan et al., 1997)

Suppresses the pupal lethality of N^Ax-9/N^Ax-E2. Adult flies show a subset of dx phenotypes: outstretched wings, variably-fused ocelli.

(Diederich et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

N^su42c has visible | dominant phenotype, enhanceable by Df(3R)Delta-FX3

(Brennan et al., 1997)

Suppressed by

Statement

Reference

N^su42c has visible | dominant phenotype, suppressible by wg^S107

(Brennan et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

N^su42c has adult thoracic sensillum phenotype, enhanceable by Df(3R)Delta-FX3

(Brennan et al., 1997)

Suppressed by

Statement

Reference

N^su42c has adult thoracic sensillum phenotype, suppressible by wg^S107

(Brennan et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

The number of thoracic bristles is increased further in hemizygous or Df(3R)Dl-FX3 ; N^su42c double heterozygous flies, and the number of bristles is restored almost to wild-type in N^su42c ; wg^S107 double heterozygotes.

(Brennan et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

N^Ax-M1

(Brennan et al., 1997)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

The new and parental lesions in N^su42c are separable by recombination.

(Diederich et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

N^su42c

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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