FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pka-C1C2
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General Information
Symbol
Dmel\Pka-C1C2
Species
D. melanogaster
Name
FlyBase ID
FBal0033956
Feature type
allele
Associated gene
Dmel\Pka-C1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Li et al., 1995)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: G128D.

    (Lane and Kalderon, 1993)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2L:9,697,184..9,697,184 [-]
    Nucleotide change:

    G9697184A

    Reported nucleotide change:

    G2506A

    Amino acid change:

    G128D | Pka-C1-PB; G128D | Pka-C1-PC; G128D | Pka-C1-PD

    Reported amino acid change:

    G128D

    (Lane and Kalderon, 1993)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Imaginal pattern duplications. Wings carrying mutant clones extending to the wing margin exhibit ectopic tissue and pattern alterations induced by clones in the anterior compartment, pattern alterations included and extended beyond the location of clones. Similar pattern of phenotype is seen in the anterior leg regions.

        (Li et al., 1995)

        Hemizygotes are larval lethal. Mature oocytes are smaller than wild type and nurse cells are multinucleate.

        (Lane and Kalderon, 1993)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT Enhancer of
        Statement
        Reference

        Pka-C1[+]/Pka-C1C2 is a non-enhancer of abnormal neuroanatomy | adult stage phenotype of sws1

        (Bettencourt da Cruz et al., 2008)
        Phenotype Manifest In
        NOT Enhancer of
        Statement
        Reference

        Pka-C1[+]/Pka-C1C2 is a non-enhancer of neuropil | adult stage phenotype of sws1

        (Bettencourt da Cruz et al., 2008)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Pka-C1C2/+ does not enhance vacuole formation in sws1/sws1 flies.

        (Bettencourt da Cruz et al., 2008)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Partially rescued by

        Pka-C1C2 is partially rescued by Pka-C1+mTgDC0

        (Lane and Kalderon, 1993)
        Comments

        One copy of Pka-C1+mTgDC0 provides partial rescue of hemizygotes.

        (Lane and Kalderon, 1993)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Strong Pka-C1 allele.

        (Lane and Kalderon, 1993)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        DCOC2
        (Li et al., 1995)
        PKA-C1C2
        (Bettencourt da Cruz et al., 2008)
        Pka-C1C2
        Name Synonyms
        Secondary FlyBase IDs
          References (3)