FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\enCX1
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General Information
Symbol
Dmel\enCX1
Species
D. melanogaster
Name
FlyBase ID
FBal0034500
Feature type
allele
Associated gene
Dmel\en
Associated Insertion(s)
Carried in Construct
Also Known As
enCXI
Key Links
Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Manoukian et al., 1995, Heemskerk et al., 1991)

    loss of function allele

    (Andrew et al., 1997)
    Mutagen
    Progenitor genotype
    Caused by aberration
    In(2R)enCX1
    Cytology
    Description

    Breakpoint mutation within the first intron or exon.

    (Whiteley and Kassis, 1997)

    Maps to approximate coordinate -14 of the inv-en region. The rearrangement associated wth this allele severs the en transcription unit in either the first exon or the first intron, separating the sequences that control expression in the hindgut and clypeolabrum from those that control expression in the ectoderm and nervous system.

    (Gustavson et al., 1996)

    Inversion breakpoint within the transcription unit.

    (Saenz-Robles et al., 1995)

    A rearrangement that truncates the en transcription unit.

    (Heemskerk et al., 1991)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous embryos lack antennal sense organs.

        (Gallitano-Mendel and Finkelstein, 1998)

        Double mutant phenotype with CrebA mutants is additive.

        (Andrew et al., 1997)

        Strong mutant phenotype. Mutant embryos develop extreme denticle belt fusions and show a severe segmentation phenotype. This phenotype is comparable to that of embryos deleted for both en and inv. enCX1/en1 adults have severely disrupted wings, legs with fused tarsal segments and a low frequency of eclosion.

        (Gustavson et al., 1996)

        Pair-wise fusions of thoracic and abdominal denticle bands. Expression of P{31Rg-en} in enCX1 mutant background allows restoration of naked cuticle between fused denticle bands (good rescue of early en function), as well as near normal denticle patterns within bands (row 1 denticles are rarely rescued - partial rescue of late en function). Expression of P{enF->E} or P{enΔeh1} allows only very weak rescue; restoration of some naked cuticle between ventral denticle bands.

        (Smith and Jaynes, 1996)

        Transheterozygotes with Df(3R)slo8 produce flies with abnormal wings.

        (Saenz-Robles et al., 1995)

        Severe en phenotype.

        (Heemskerk et al., 1991)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Suppressed by
        Statement
        Reference

        enCX1 has embryo phenotype, suppressible by Agam\eninv-12A

        (Whiteley and Kassis, 1997)

        enCX1 has embryo phenotype, suppressible by Agam\enen-12A-5R

        (Whiteley and Kassis, 1997)
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference

        Agam\eninv-12A rescues many aspects of the embryonic phenotype. Agam\enen-12A-5R rescue causes slight defects in the posterior compartments of the wings, both sexes are fertile.

        (Whiteley and Kassis, 1997)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Strong en allele.

        (Smith and Jaynes, 1996)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        enCX1
        enCXI
        (Smith and Jaynes, 1996)
        enCxi
        (Edgar et al., 1994)
        enCX1
        (Lecourtois et al., 2001)
        Name Synonyms
        Secondary FlyBase IDs
          References (18)