FlyBase Allele Report: Dmel\ftz-f1[hs.PW]

General Information

Symbol

Dmel\ftz-f1^hs.PW

Species

D. melanogaster

Name

heat shock construct of Woodard

FlyBase ID

FBal0034690

Feature type

allele

Associated gene

Dmel\ftz-f1

Associated Insertion(s)

Carried in Construct

P{F-F1}

Key Links

Transgenic product class

wild_type

(Woodard et al., 1994)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Woodard et al., 1994)

Mutagen

in vitro construct

(Woodard et al., 1994)

Progenitor genotype

Carried in construct

P{F-F1}

Cytology

Description

Expression of ftz-f1 driven by an Hsp70 promoter.

(Woodard et al., 1994)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

Encoded product / tool

ftz-f1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | heat sensitive

(Neuman et al., 2014)

increased cell death | heat sensitive

(Lee et al., 2002)

Phenotype Manifest In

salivary gland | heat sensitive

(Lee et al., 2002)

Detailed Description

Statement

Reference

The timing of head eversion is accelerated by almost 2 hours compared to controls in animals in which expression of ftz-f1^hs.PW is induced by a heat shock at 6 hours after puparium formation.

(Neuman et al., 2014)

The salivary glands of mutant pupae heatshocked at 37^oC and aged to 6 hours APF, do not have salivary glands, and the degraded remnants exhibit signs of DNA fragmentation and thus cell death.

(Lee et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

ftz-f1^hs.PW has increased cell death | heat sensitive phenotype, suppressible by Idh3b¹/Df(3R)93F^x2

(Lee et al., 2002)

Suppressor of

Statement

Reference

ftz-f1^hs.PW is a suppressor | heat sensitive of abnormal developmental rate phenotype of Ino80^psg25/Df(3R)ED5942

(Neuman et al., 2014)

Phenotype Manifest In

Suppressed by

Statement

Reference

ftz-f1^hs.PW has salivary gland | heat sensitive phenotype, suppressible by Idh3b¹/Df(3R)93F^x2

(Lee et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of ftz-f1^hs.PW is induced by a heat shock at 7 hours after puparium formation rescues the timing of head eversion in Ino80^psg25/Df(3R)ED5942 animals to normal.

(Neuman et al., 2014)

The addition of Idh3b¹/Df(3R)93F^x2 to heat shocked ftz-f1^hs.PW animals leads to a reduction in the cell death seen in salivary glands (and thus intact salivary glands) though DNA fragmentation is still seen.

(Lee et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

ftz-f1^hs.PW partially rescues ftz-f1¹⁷

(Broadus et al., 1999)

Comments

Heat shock of ftz-f1^hs.PW applied at 29^oC after 2.5 hours of prepupal development at 25^oC rescues the lethality of ftz-f1¹⁷ to 60%.

(Broadus et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ftz-f1^hs.PW

Name Synonyms

heat shock construct of Woodard

(Woodard et al., 1994)

Secondary FlyBase IDs

References (5)

Report Sections

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