FlyBase Allele Report: Dmel\ifc[4]

General Information

Symbol

Dmel\ifc⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0034809

Feature type

allele

Associated gene

Dmel\ifc

Associated Insertion(s)

P{A92}ifc⁴

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Castrillon et al., 1993)

Progenitor genotype

Associated Insertion(s)

P{A92}ifc⁴

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{A92}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of obesity

CEA

(Villanueva et al., 2019, Walls et al., 2013)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal starvation stress response | adult stage

(Walls et al., 2013)

increased cell size | adult stage

(Walls et al., 2013)

male sterile

(Castrillon et al., 1993)

Phenotype Manifest In

adult fat body

(Walls et al., 2013)

lipid droplet | adult stage

(Walls et al., 2013)

spermatocyte

(Castrillon et al., 1993)

testis

(Castrillon et al., 1993)

Detailed Description

Statement

Reference

ifc⁴ homozygous mutant adults present significantly increased survival to starvation, increased body weight, increased adiposity in abdominal sections, and increased sizes of fat body cells and lipid droplets, as compared to controls.

ifc⁴ homozygous mutant adults present similar feeding behavior to controls, as assessed by postprandial meal volume, average meal frequency and volume, and caloric intake.

(Walls et al., 2013)

Testes are short and filled with cysts of 16-cell spermatocytes, which degenerate prior to completion of the growth phase.

(Castrillon et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ifc⁴ has abnormal starvation stress response | adult stage phenotype, enhanceable by Sk2^KG05894/Sk2^KG05894

(Walls et al., 2013)

NOT Enhanced by

Statement

Reference

ifc⁴ has increased cell size | adult stage phenotype, non-enhanceable by Sk2^KG05894/Sk2^KG05894

(Walls et al., 2013)

Enhancer of

Statement

Reference

ifc⁴/ifc⁴ is an enhancer of abnormal starvation stress response | adult stage phenotype of Sk2^KG05894

(Walls et al., 2013)

ifc⁴/ifc⁴ is an enhancer of abnormal feeding behavior | adult stage phenotype of Sk2^KG05894

(Walls et al., 2013)

NOT Enhancer of

Statement

Reference

ifc⁴/ifc⁴ is a non-enhancer of increased cell size | adult stage phenotype of Sk2^KG05894

(Walls et al., 2013)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

ifc⁴ has adult fat body phenotype, non-enhanceable by Sk2^KG05894/Sk2^KG05894

(Walls et al., 2013)

ifc⁴ has lipid droplet | adult stage phenotype, non-enhanceable by Sk2^KG05894/Sk2^KG05894

(Walls et al., 2013)

NOT Enhancer of

Statement

Reference

ifc⁴/ifc⁴ is a non-enhancer of adult fat body phenotype of Sk2^KG05894

(Walls et al., 2013)

ifc⁴/ifc⁴ is a non-enhancer of lipid droplet | adult stage phenotype of Sk2^KG05894

(Walls et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Sk2^KG05894, ifc⁴ double homozygous adults present a more severe increase in survival in response to starvation as compared to either Sk2^KG05894 or ifc⁴ homozygous mutants.

The increased body weight, increased adiposity in abdominal sections, and increased sizes of fat body cells and lipid droplets observed in either ifc⁴ or Sk2^KG05894 homozygous mutant adults are not exacerbated in ifc⁴, Sk2^KG05894 double homozygous adults.

The increased starvation-induced appetite, but not the increased postprandial meal volume, the increased average meal frequency and volume, or the increased daily food intake, observed in Sk2^KG05894 homozygous mutant adults is exacerbated by ifc⁴ homozygosity.

(Walls et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

1549

P{A92}ifc⁴/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ifc⁴

(Walls et al., 2013)

l(2)26Ab⁴

(Castrillon et al., 1993)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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