FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ari-11199
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General Information
Symbol
Dmel\ari-11199
Species
D. melanogaster
Name
FlyBase ID
FBal0034851
Feature type
allele
Associated gene
Dmel\ari-1
Associated Insertion(s)
Carried in Construct
Also Known As
ari-11
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(de la Pompa, 1994, Ferrus et al., 1990)
Progenitor genotype
Cytology
Description

Amino acid replacement: ?129term.

(Aguilera et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:18,135,113..18,135,113 [-]
Nucleotide change:

C18135113T

Amino acid change:

Q129term | ari-1-PA; Q129term | ari-1-PB; Q129term | ari-1-PC; Q129term | ari-1-PD; Q129term | ari-1-PE; Q129term | ari-1-PF

Reported amino acid change:

?129term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Aguilera et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult male survivors are seen at a low frequency (less than 10%). ari-11199/ari-13747 animals are viable. The paternal introduction of ari-13747 results in 30% viability, while viability drops to 3% if ari-13747 is introduced maternally. ari-11199/ari-13747 females have an abnormally small number of ovarioles and arrested cyst development is occasionally seen. ari-11199/ari-13747 escapers show severe structural defects in the tergal depressor of the trochanter (TDT) muscle. The DVMII muscles appear reduced in size but with a relatively normal structure. The negative sustained component of the electroretinogram of mutant escapers is reduced to 1/3 of controls. The amplitude of the on and off transients is reduced by approximately 30%. Females carrying homozygous germline clones can produce offspring, indicating that the ari-11199 mutation does not prevent oogenesis.

      (Aguilera et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Heterozygotes with wupA8384 are poorly viable.

      (de la Pompa, 1994)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Induced on: a f5 osunspecified chromosome.

      (Aguilera et al., 2000)
      Comments
      Comments

      Mutation in the haplo-lethal (HL) region of the Sh complex.

      (Ferrus et al., 1990)

      Mutation within the haplo-lethal (HL) region of the Sh complex.

      (de la Pompa, 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      ari-11199
      ari-11
      (Ramírez et al., 2021, Aguilera et al., 2000)
      ari1199
      (Ferrus, 1999.3.4, Ferrus et al., 1990)
      l(1)1199
      (de la Pompa, 1994)
      l(1)16Fj1199
      Name Synonyms
      Secondary FlyBase IDs
        References (5)