FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\wupA8384
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General Information
Symbol
Dmel\wupA8384
Species
D. melanogaster
Name
FlyBase ID
FBal0036020
Feature type
allele
Associated gene
Dmel\wupA
Associated Insertion(s)
Carried in Construct
Also Known As
8384SDL
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(de la Pompa, 1994)
Mutagen
X ray
(Prado et al., 1999, de la Pompa, 1994, Barbas et al., 1991, Ferrus et al., 1990)
Progenitor genotype
Cytology
Description

Insertion of approximately 8kb in the region between exons 2 and 3.

(Prado et al., 1999)

6kb insertion at map position 209.

(Barbas et al., 1991)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      wupA8384 males die during embryogenesis and have hypodermal and neural phenotypes. wupA8384/+ females that do not survive die at the embryonic or first larval instar stages. Those that survive to eclosion (10-30%) have normal morphology. The semi-dominant lethality of wupA8384 is not complemented by l(1)16Fe1 or the '23437' chromosome (in which l(1)16Fm and l(1)16Fe are affected).

      (Prado et al., 1999)

      Embryos have a thin layer of cuticle in the cephalic region. Heterozygotes with wupAhdp-3 have only remnants of the degenerating fibrillar muscles (dorsal-longitudinal muscle, DLM and dorso-ventral muscle, DVM) and no tergal depressor of trochanter muscle (TDT). Heterozygous females are 30% viable.

      (de la Pompa, 1994)

      Abnormal embryonic development: thin layer of cuticle but no hypoderm or muscles are found at the postgnathal-thoracic region.

      (Barbas et al., 1991)

      Flies manifest chronic vibration of their appendages as well as abnormal action potentials.

      (Ferrus et al., 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Heterozygotes with l(1)16Fb2, por15175, ari-11199, l(1)16Ff2288 and l(1)16Fl3014 are poorly viable. Heterozygotes with l(1)16Fc1 are poorly viable.

      (de la Pompa, 1994)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Mutation in the haplo-lethal (HL) region of the Sh complex.

      (Ferrus et al., 1990)

      Mutation within the haplo-lethal (HL) region of the Sh complex.

      (de la Pompa, 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      8384SDL
      (Casas-Tintó and Ferrús, 2021, Prado et al., 1999)
      l(1)8384
      (de la Pompa, 1994)
      wupA8384
      Name Synonyms
      Secondary FlyBase IDs
        References (5)