FlyBase Allele Report: Dmel\ari-1[3747]

General Information

Symbol

Dmel\ari-1³⁷⁴⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0095524

Feature type

allele

Associated gene

Dmel\ari-1

Associated Insertion(s)

Carried in Construct

Also Known As

ari-1²

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: C150Y.

(Aguilera et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:18,134,341..18,134,341 [-]

Nucleotide change:

G18134341A

Amino acid change:

Reported amino acid change:

C150Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Aguilera et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Parkinson's disease

modeled by comt⁶

(Ramírez et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult optic lobe

(Aguilera et al., 2000)

coxal tergal remotor muscle cell (with ari-1¹¹⁹⁹)

(Aguilera et al., 2000)

embryonic/larval neuromuscular junction | larval stage

(Ramírez et al., 2021)

germline cyst (with ari-1¹¹⁹⁹)

(Aguilera et al., 2000)

germline cyst (with Dp(1;3)JC153)

(Aguilera et al., 2000)

mesothoracic tergotrochanter muscle cell (with ari-1¹¹⁹⁹)

(Aguilera et al., 2000)

ovariole (with ari-1¹¹⁹⁹)

(Aguilera et al., 2000)

ovariole (with Dp(1;3)JC153)

(Aguilera et al., 2000)

photoreceptor cell R1 & rough endoplasmic reticulum | somatic clone

(Aguilera et al., 2000)

photoreceptor cell R2 & rough endoplasmic reticulum | somatic clone

(Aguilera et al., 2000)

photoreceptor cell R3 & rough endoplasmic reticulum | somatic clone

(Aguilera et al., 2000)

photoreceptor cell R4 & rough endoplasmic reticulum | somatic clone

(Aguilera et al., 2000)

photoreceptor cell R5 & rough endoplasmic reticulum | somatic clone

(Aguilera et al., 2000)

photoreceptor cell R6 & rough endoplasmic reticulum | somatic clone

(Aguilera et al., 2000)

photoreceptor cell R7 & rough endoplasmic reticulum | somatic clone

(Aguilera et al., 2000)

rhabdomere R1 | somatic clone

(Aguilera et al., 2000)

rhabdomere R2 | somatic clone

(Aguilera et al., 2000)

rhabdomere R3 | somatic clone

(Aguilera et al., 2000)

rhabdomere R4 | somatic clone

(Aguilera et al., 2000)

rhabdomere R5 | somatic clone

(Aguilera et al., 2000)

rhabdomere R6 | somatic clone

(Aguilera et al., 2000)

Detailed Description

Statement

Reference

ari-1³⁷⁴⁷ repressively leads to a decrease in the frequency of spontaneous miniature events and increased postsynaptic evoked synaptic currents in the larval neuromuscular junction; three are also decreases in the frequency of synaptic failure events.

(Ramírez et al., 2021)

Mutants show no obvious mushroom body defect.

(Watts et al., 2003)

ari-1¹¹⁹⁹/ari-1³⁷⁴⁷ animals are viable. The paternal introduction of ari-1³⁷⁴⁷ results in 30% viability, while viability drops to 3% if ari-1³⁷⁴⁷ is introduced maternally. ari-1¹¹⁹⁹/ari-1³⁷⁴⁷ females have an abnormally small number of ovarioles and arrested cyst development is occasionally seen. ari-1¹¹⁹⁹/ari-1³⁷⁴⁷ escapers show severe structural defects in the tergal depressor of the trochanter (TDT) muscle. The DVMII muscles appear reduced in size but with a relatively normal structure. Gynandromorphs show defects in the optic ganglion. The optic tract normally found between the medulla and the lobula complex may project directly towards the brain instead. In adult mosaic retina, photoreceptors show a 13% reduction in the average R1-6 rhabdomere area compared to wild type. A severe reduction of the rough endoplasmic reticulum is seen in the mutant cells. This reduction is seen in photoreceptors R1-R7 within the mutant clone. Females carrying homozygous germline clones yield defective eggs that are unable to sustain development, irrespective of their zygotic genotype. These abortive embryos do not reach the blastoderm stage. ari-1³⁷⁴⁷/ari-1³⁷⁴⁷/Dp(1;3)JC153 females are sterile. The number of ovarioles is abnormally small and arrested cyst development is occasionally seen. Embryos derived from these females can show patchy differentiation of abdominal setae belts.

(Aguilera et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

ari-1³⁷⁴⁷ has lethal phenotype, suppressible | partially by +/Df(2R)Drl^rv7

(Gradilla et al., 2011)

ari-1³⁷⁴⁷ has lethal phenotype, suppressible | partially by CG15523[+]/Vps13B^KG07288

(Gradilla et al., 2011)

ari-1³⁷⁴⁷ has lethal phenotype, suppressible | partially by bon^21B/bon[+]

(Gradilla et al., 2011)

ari-1³⁷⁴⁷ has lethal phenotype, suppressible | partially by EcR¹¹²/EcR[+]

(Gradilla et al., 2011)

ari-1³⁷⁴⁷ has lethal phenotype, suppressible | partially by EcR[+]/EcR²²⁵

(Gradilla et al., 2011)

ari-1³⁷⁴⁷ has lethal phenotype, suppressible | partially by EcR^M554fs/EcR[+]

(Gradilla et al., 2011)

ari-1³⁷⁴⁷ has lethal phenotype, suppressible | partially by ftz-f1[+]/ftz-f1⁰³⁶⁴⁹

(Gradilla et al., 2011)

NOT suppressed by

Statement

Reference

ari-1³⁷⁴⁷ has lethal phenotype, non-suppressible by Eip78C^A464.2M3/Eip78C[+]

(Gradilla et al., 2011)

ari-1³⁷⁴⁷ has lethal phenotype, non-suppressible by Eip75B^KG03025/Eip75B[+]

(Gradilla et al., 2011)

ari-1³⁷⁴⁷ has lethal phenotype, non-suppressible by Cth^KG02526/Eip55E[+]

(Gradilla et al., 2011)

Enhancer of

Statement

Reference

ari-1³⁷⁴⁷/ari-1[+] is an enhancer of paralytic | heat sensitive phenotype of comt⁶

(Ramírez et al., 2021)

Other

Statement

Reference

Scer\GAL4^αTub84B.PL, ari-1³⁷⁴⁷, ari-1^UAS.cFa, usp⁴/usp[+] has lethal | second instar larval stage phenotype

(Gradilla et al., 2011)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Induced on: a y^unspecified w^unspecified wupA^hdp-3 chromosome.

(Aguilera et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

ari-1²

(Ramírez et al., 2021, Watts et al., 2003, Aguilera et al., 2000)

ari-1³⁷⁴⁷

ari-1a²

(Gradilla et al., 2011)

ari²

(Ramírez et al., 2021)

ari³⁷⁴⁷

(Ferrus, 1999.3.4)

Name Synonyms

Secondary FlyBase IDs

References (5)

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