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General Information
Symbol
Dmel\ftz-f103649
Species
D. melanogaster
Name
FlyBase ID
FBal0009477
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ftz-f1l(3)03649, l(3)03649
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{PZ} element insertion near the transcription start site.

P{PZ} is inserted into the ftz-f1 coding region.

Insertion components
P{PZ}ftz-f103649
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In ftz-f1ex7/ftz-f103649 mutants, no pupation occurs; when ftz-f1hs.PM is induced at 8hr APF or later, pupation occurs and is delayed (length of delay depends on the timing of the heat shock).

Most ftz-f1ex7/ftz-f103649 transheterozygotes die before reaching the prepupal stage, but 3% do progress to prepupae. The development of this 3% arrests before prepupal stage P4. Larval salivary glands are still present even 24 hours after puparium formation (in contrast to wild type). The optic lobes do not expand as in wild type and the subesophageal neuromeres and thoracic neuromeres do not separate. Arrested development is also manifested as leg elongation, edge constriction of the wing disc and morphological changes in the midgut and Malpighian tubules.

Demonstrates a ftz-like pair rule phenotype.

Germline clones produce eggs with patterning defects: pair rule segmentation defects.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

ftz-f1[+]/ftz-f103649 is a suppressor | partially of lethal phenotype of ari-13747

Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Salivary gland histolysis is rescued in most ftz-f1ex7/ftz-f103649 transheterozygotes when brBRcore.TNT.Q1.Z1.hs is expressed using heat shock at 10 hours after puparium formation, although other ftz-f1 mutant phenotypes are not rescued in these animals. Salivary gland histolysis is rescued in about half of ftz-f1ex7/ftz-f103649 transheterozygotes when brZ2.hs is expressed using heat shock at 10 hours after puparium formation. Salivary gland histolysis is not rescued in ftz-f1ex7/ftz-f103649 transheterozygotes when either brBRcore.NS.Z3.hs or brBRcore.Z4.hs is expressed using heat shock at 10 hours after puparium formation.

The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by ftz-f103649.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Partially rescued by
Comments

In ftz-f1ex7/ftz-f103649 mutants, no pupation occurs when ftz-f1hs.PM is induced at 4 or 5hr APF, but 75 or 100% of animals become pupa at 12.3 or 12.6 APF on average when ftz-f1hs.PM is induced at 6 or 7hr APF, respectively.

ftz-f1hs.PM rescues ftz-f1ex7/ftz-f103649 animals that are arrested as prepupae before stage P4; the rescued animals are able to become pupae and a fraction of them develop until at least stage P12. Efficient rescue is seen when the animals are heat shocked 6-10 hours after puparium formation.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

A. Spradling.

Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (18)