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General Information
Symbol
Dmel\brBRcore.Z4.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0057738
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
hs-BR-Z4
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Over-expression of four copies of brBRcore.Z4.hs using heat shock at 5 hours after ecdysis to the second instar causes a high rate of lethality at approximately 26 hours after the heat shock (the time of ecdysis from second to third instar). Double mouthhooks are seen in these dead larvae.

Animals carrying four copies of brBRcore.Z4.hs and heat shocked at 56 hours after puparium formation have essentially full length bristles that are unpigmented. The sockets of the macrochaetae are also not tanned.

In response to heatshock, ectopic dorsal appendage material is produced in the dorsal anterior region of the eggshell. 0-3 hours post heatshock about 5% of the eggs produced are abnormal, and 95% of eggs laid hatch. 3-5 post heatshock 43% of the eggs produced are abnormal, and only 4% of eggs laid hatch. From 5-24 hours post heatshock about 3/4 of eggs produced are abnormal, and 15% of eggs laid hatch. 24-48 hours post heatshock, about a 1/5 of eggs produced are abnormal, and 97% of eggs laid hatch. Viability is recovered to about 95% in 2 days after heatshock.

A 37oC heat shock causing expression of brBRcore.Z4.hs during the third larval instar or early prepupal stage results in lethality within a few hours of the heat shock. Heat shock induced expression of brBRcore.Z4.hs during late prepupal or pupal stages has no effect.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Salivary gland histolysis is not rescued in ftz-f1ex7/ftz-f103649 transheterozygotes when brBRcore.Z4.hs is expressed using heat shock at 10 hours after puparium formation.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of one copy of brBRcore.Z4.hs in brrbp-1 mutant flies results rescue of only 7% of animals to eclosion. This increases to 13% when two copies are used. Mutant brrbp-1 flies rescued with brBRcore.Z4.hs typically die within 1-2 days of eclosion. These animals have a protracted proboscis and are most likely unable to feed. The malformed leg phenotype found in brrbp-1 animals that develop to late pupal stages is rescued in approximately 50% of cases by the expression of two brBRcore.Z4.hs transgenes.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

The br Z4 protein isoform encoded by brBRcore.Z4.hs provides partial rbp+ function.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
brBRcore.Z4.hs
Name Synonyms
Secondary FlyBase IDs
    References (11)