FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\brnpr-7
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General Information
Symbol
Dmel\brnpr-7
Species
D. melanogaster
Name
FlyBase ID
FBal0013161
Feature type
allele
Associated gene
Dmel\br
Associated Insertion(s)
Carried in Construct
Also Known As
npr17
Key Links
Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(O'Keefe et al., 1995, Restifo and Merrill, 1994, DiBello et al., 1991)

loss of function allele

(Bayer et al., 1997)
Mutagen
diepoxybutane
(Bayer et al., 1997, O'Keefe et al., 1995, Restifo and Merrill, 1994, Kiss et al., 1988)
Progenitor genotype
Caused by aberration
T(1;3)npr1
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes arrest development at the end of the larval period, do not pupariate and die after several days as wandering third instar larvae.

      (Bayer et al., 1997)

      Lethality acts in the late third instar.

      (Emery et al., 1994)

      Heterozygotes with br1 display small maxillary palps that are virtually devoid of mechanosensory bristles. Rostral membrane is lost so the proboscis is barely visible.

      (Restifo and Merrill, 1994)

      Failure of salivary gland degeneration. Reduction in dorso-ventral class of indirect flight muscles.

      (Restifo and White, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      br1

      (Restifo and Merrill, 1994)
      Partially rescued by

      brnpr-7 is partially rescued by brZ2.hs

      (Bayer et al., 1997)
      Not rescued by

      brnpr-7 is not rescued by brBRcore.Z4.hs

      (Bayer et al., 1997)

      brnpr-7 is not rescued by brBRcore.Q1.Z1.hs

      (Bayer et al., 1997)

      brnpr-7 is not rescued by brBRcore.NS.Z3.hs

      (Bayer et al., 1997)

      brnpr-7 is not rescued by brBRcore.TNT.Q1.Z1.hs

      (Bayer et al., 1997)
      Comments

      Lethality is not rescued by brBRcore.Q1.Z1.hs, brBRcore.TNT.Q1.Z1.hs, brZ2.hs, brBRcore.NS.Z3.hs or brBRcore.Z4.hs when expressed using heat shocks of either 33oC or 37oC. brnpr-7 third instar larvae expressing brZ2.hs show further development than control brnpr-7 larvae, forming normal looking puparia with everted spiracles, a tanned cuticle and imaginal discs that have initiated morphogenesis.

      (Bayer et al., 1997)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (12)