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General Information
Symbol
Dmel\brBRcore.Q1.Z1.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0057741
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

br cDNA dm527 is expressed from a heat inducible Hsp70 promoter.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Over-expression of four copies of the br Z1 isoform (using a line containing both brBRcore.TNT.Q1.Z1.hs and brBRcore.Q1.Z1.hs) using heat shock at 5 hours after ecdysis to the second instar causes lethality at approximately 42-68 hours after the heat shock with no detectable third instar mouthhooks.

Animals carrying two copies of brBRcore.TNT.Q1.Z1.hs and two copies of brBRcore.Q1.Z1.hs that have been heat shocked between 45 and 52 hours after puparium formation (APF) form pharate adults with a transparent cuticle on many areas of the head, thorax and abdomen. The microchaetae and macrochaetae are present, and are sometimes slightly tanned. Dorsolateral areas of the abdomen sometimes show the beginning of adult melanisation that extends into the anterior region of the tergite where melanisation is not normally found. Animals carrying two copies of brBRcore.TNT.Q1.Z1.hs and two copies of brBRcore.Q1.Z1.hs that have been heat shocked between 30-35 hours APF show truncation of bristles on the head and thorax. Animals carrying two copies of brBRcore.TNT.Q1.Z1.hs and two copies of brBRcore.Q1.Z1.hs that have been heat shocked between 35-39 hours APF show truncation of bristles on the abdomen. Animals carrying two copies of brBRcore.TNT.Q1.Z1.hs and two copies of brBRcore.Q1.Z1.hs that have been heat shocked at 35 or 39 hours APF lack abdominal trichomes.

A 37oC heat shock causing expression of brBRcore.Q1.Z1.hs during the third larval instar or early prepupal stage results in lethality within a few hours of the heat shock. Heat shock induced expression of brBRcore.Q1.Z1.hs during late prepupal or pupal stages has no effect.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Z1 isoforms provide the rbp+ function in prepupal salivary glands.

The br Z1 protein isoform encoded by brBRcore.Q1.Z1.hs provides full rbp+ function.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
brBRcore.Q1.Z1.hs
Name Synonyms
Secondary FlyBase IDs
    References (6)