FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mv1
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General Information
Symbol
Dmel\mv1
Species
D. melanogaster
Name
FlyBase ID
FBal0035239
Feature type
allele
Associated gene
Dmel\mv
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Caused by aberration
    In(3LR)264
    Cytology
    Description

    Inversion breakpoint in mv, resulting in a fusion protein connecting codons 1-2772 of mv with nucleotide 853 of isoform 4 of tacc.

    (Rahman et al., 2012)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  Chediak-Higashi syndrome
        CEA with mv3
        (Lattao et al., 2021)
        CEA with mvros
        (Lattao et al., 2021)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Stage 4 embryos from mv3/mv1 or mvros/mv1 mothers show multiple centrosomes often in chains.

        Embryos from mvros/Df(3L)R-G7 mothers show: a) aberrant mitotic spindles of different sizes associated with varying amounts of DNA, abnormal chromosome segregation and multiple centrosomes often in chains; b) reach the syncytial blastoderm stage but exhibit localized MTOC inactivation and loss of contact between nuclei and centrosomes at the cortex, leading nuclei to sink into the interior of the embryo (nuclear fallout).

        (Lattao et al., 2021)

        Eye colour: dark.

        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer

        Loring Craymer.

        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        mv1
        (Lattao et al., 2021, Rahman et al., 2012)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)