FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sev::tor13D.hs.sev
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General Information
Symbol
Dmel\sev::tor13D.hs.sev
Species
D. melanogaster
Name
FlyBase ID
FBal0035595
Feature type
allele
Associated gene
sev::tor
Associated Insertion(s)
Carried in Construct
P{sE-torso4021-sev}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Freeman, 1996, Reichman-Fried et al., 1994, Dickson et al., 1992)
Progenitor genotype
tor13D
(Dickson et al., 1992)
Carried in construct
P{sE-torso4021-sev}
Cytology
Description

sev intracellular kinase domain replaces the equivalent region from tor13D, expression of the chimera is driven by an Hsp70 promoter and a single copy of the 1.2kb sev enhancer.

(Reichman-Fried et al., 1994)

The tor region contains same amino acid replacement as in tor13D gain of function allele. Expression is under the influence of the sev enhancer and the Hsp70 promoter.

(Dickson et al., 1992)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
sev
Encoded product / tool
sev::tor
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Rough eye phenotype.

      (Dong et al., 1999)

      Homozygotes exhibit extra outer photoreceptor cells, the recruitment as neurons of the mystery cells. Ommatidia also exhibit extra cone and primary pigment cells, independent of the number of receptor cells.

      (Freeman, 1996)

      Partial rescue of tracheal migration defect in btl homozygotes.

      (Reichman-Fried et al., 1994)

      In a sev- background, flies have rough eyes. Similar to sevS11.T:Hsap\MYC : transformation of mystery and cone cells into R7. Stronger effect than for sev::tor12D.hs.sev. Phenotype shows cold sensitivity. Phenotype shown to act through sev kinase, compare to sev::tor13D:K2242M.hs.sev.

      (Dickson et al., 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      sev::tor13D.hs.sev has phenotype, suppressible by Sos34Ea-6

      (Dong et al., 1999)

      sev::tor13D.hs.sev has photoreceptor cell R7 phenotype, suppressible by drkR1

      (Raabe et al., 1995)
      NOT suppressed by
      Statement
      Reference

      sev::tor13D.hs.sev has eye phenotype, non-suppressible by ebiE90

      (Dong et al., 1999)
      Suppressor of
      Statement
      Reference

      sev::tor13D.hs.sev is a suppressor of wing vein L4 phenotype of Egfrf3/Egfrt2

      (Freeman, 1996)
      Other
      Statement
      Reference

      sev::tor13D.hs.sev, sev14 has ommatidium phenotype

      (Raabe et al., 1995)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Egfrf3/Egfrt2 wings have a gap in L4 wing vein. Vein gap can be rescued by one copy of sev::tor13D.hs.sev. Ectopic expression also causes extra vein phenotype, notably around the distal end of L2 and broadening or deltas at the distal tips of most of the veins.

      (Freeman, 1996)

      In a sev14 background, flies carrying one copy of sev::tor13D.hs.sev have rough eyes with 99% of the ommatidia having multiple R7 cells. Number of R7 cells per ommatidium is 3.8 +/- 1.0 (n=128). sev::tor13D.hs.sev; drkR1/+ flies have 33% of ommatidia with multiple R7 cells as opposed to 99% for sev::tor13D.hs.sev flies.

      (Raabe et al., 1995)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Used to study effects of constitutive activation of sev using tor sequences from gain of function tor alleles.

      (Dickson et al., 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Tor4021-sev
      (Raabe et al., 1996)
      sev::tor13D.hs.sev
      tor-sev
      (Reichman-Fried et al., 1994)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0039897
      References (7)