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General Information
Symbol
Dmel\sev::tor13D.hs.sev
Species
D. melanogaster
Name
FlyBase ID
FBal0035595
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

sev intracellular kinase domain replaces the equivalent region from tor13D, expression of the chimera is driven by an Hsp70 promoter and a single copy of the 1.2kb sev enhancer.

The tor region contains same amino acid replacement as in tor13D gain of function allele. Expression is under the influence of the sev enhancer and the Hsp70 promoter.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Rough eye phenotype.

Homozygotes exhibit extra outer photoreceptor cells, the recruitment as neurons of the mystery cells. Ommatidia also exhibit extra cone and primary pigment cells, independent of the number of receptor cells.

Partial rescue of tracheal migration defect in btl homozygotes.

In a sev- background, flies have rough eyes. Similar to sevS11.T:Hsap\MYC : transformation of mystery and cone cells into R7. Stronger effect than for sev::tor12D.hs.sev. Phenotype shows cold sensitivity. Phenotype shown to act through sev kinase, compare to sev::tor13D:K2242M.hs.sev.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference

sev::tor13D.hs.sev has phenotype, suppressible by Sos34Ea-6

NOT suppressed by
Statement
Reference

sev::tor13D.hs.sev has eye phenotype, non-suppressible by ebiE90

Suppressor of
Statement
Reference

sev::tor13D.hs.sev is a suppressor of wing vein L4 phenotype of Egfrf3/Egfrt2

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Egfrf3/Egfrt2 wings have a gap in L4 wing vein. Vein gap can be rescued by one copy of sev::tor13D.hs.sev. Ectopic expression also causes extra vein phenotype, notably around the distal end of L2 and broadening or deltas at the distal tips of most of the veins.

In a sev14 background, flies carrying one copy of sev::tor13D.hs.sev have rough eyes with 99% of the ommatidia having multiple R7 cells. Number of R7 cells per ommatidium is 3.8 +/- 1.0 (n=128). sev::tor13D.hs.sev; drkR1/+ flies have 33% of ommatidia with multiple R7 cells as opposed to 99% for sev::tor13D.hs.sev flies.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Used to study effects of constitutive activation of sev using tor sequences from gain of function tor alleles.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Tor4021-sev
sev::tor13D.hs.sev
Name Synonyms
Secondary FlyBase IDs
  • FBal0039897
References (7)