FB2026_02 , released June 18, 2026
Allele: Dmel\tsl604
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General Information
Symbol
Dmel\tsl604
Species
D. melanogaster
Name
FlyBase ID
FBal0035848
Feature type
allele
Associated gene
Dmel\tsl
Associated Insertion(s)
P{white-un4}tsl604
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Martin et al., 1994)
Progenitor genotype
Associated Insertion(s)
P{white-un4}tsl604
Cytology
Description

P-element insertion between the tsl and Caki transcription units.

(Martin and Ollo, 1996)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pupariation is delayed in tsl604/Df(3R)cakiX-313 mutant larvae.

      Pupariation is delayed in homozygous tsl604 mutant larvae.

      (Grillo et al., 2012)

      tsl604 mutant embryos exhibit anterior terminal structure defects. The dorsal bridge is absent in 100% of embryos.

      (Furriols et al., 2007)

      Lack anterior most head structures and all structures posterior to abdominal segment 7. Females carrying one copy of the P{hsp-tsl} construct produce embryos that display a tor phenotype. Some embryos are almost wild type showing only weak rescue of head defects. Injection of tslco51b transcripts, synthesised in vitro from tsl cDNA, into the posterior region of early embryos causes some posterior rescue in larvae.

      (Martin et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      tsl604 is rescued by Scer\GAL4tsl.G/tslUAS.cSa

      (Furriols et al., 2007)
      Partially rescued by

      tsl604 is partially rescued by tslUAS.cSa/Scer\GAL4slbo.2.6

      (Furriols et al., 2007)

      tsl604 is partially rescued by Scer\GAL4tsl.F/tslUAS.cSa

      (Furriols et al., 2007)
      Comments

      Expression of tslScer\UAS.cSa under the control of Scer\GAL4slbo.2.6 rescues the anterior terminal structure defects seen in tsl604 mutant embryos, with 100% of embryos having a dorsal bridge. However, many of the embryos have head involution defects, meaning that only embryos with normal head involution could be examined. The posterior phenotype is also rescued, but not in all embryos.

      Expression of tslScer\UAS.cSa under the control of Scer\GAL4tsl.G rescues the anterior and posterior terminal structure defects seen in tsl604 mutant embryos, with 100% of embryos having a dorsal bridge.

      Expression of tslScer\UAS.cSa under the control of Scer\GAL4tsl.F rescues the anterior and terminal structure defects seen in tsl604 mutant embryos, with 100% of embryos having a dorsal bridge. The posterior phenotypes are not rescued.

      (Furriols et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      tsl604
      (Grillo et al., 2012, Furriols et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)