FlyBase Allele Report: Dmel\RasGAP1[sxt-BJ61]

General Information

Symbol

Dmel\RasGAP1^sxt-BJ61

Species

D. melanogaster

Name

FlyBase ID

FBal0038842

Feature type

allele

Associated gene

Dmel\RasGAP1

Associated Insertion(s)

P{lacZ}RasGAP1^sxt-BJ61

Carried in Construct

Also Known As

Gap1^BJ61

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Rogge et al., 1992)

Mutagen

P-element activity

(Boube et al., 1997, Rogge et al., 1992)

Progenitor genotype

Associated Insertion(s)

P{lacZ}RasGAP1^sxt-BJ61

Cytology

Description

Insertion of a P{lacZ} element.

(Boube et al., 1997)

Allele components

Component

Use(s)

Inserted element

P{lacZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | recessive

(Rogge et al., 1992)

Phenotype Manifest In

ommatidium

(Rogge et al., 1992)

photoreceptor cell R7

(Kolodkin et al., 1994, Rogge et al., 1992)

wing vein | ectopic

(Boube et al., 1997)

Detailed Description

Statement

Reference

Homozygotes have ectopic vein tissue in the wing.

(Boube et al., 1997)

In a sev⁶/Y, Sos^JC2/+ background, the percentage of ommatidia with R7 cells rises in heterozygotes from the 16% of sev⁶/Y, Sos^JC2/+ to 49%.

(Kolodkin et al., 1994)

Homozygotes have a rough eye appearance. Every ommatidium contains multiple (from 2 to 6) centrally projecting rhabdomeres that are morphologically similar to R7 rhabdomeres. Rhabdomeres of R1 to R6 are displaced, failing to extend the entire length of the ommatidium. In ommatidia of double mutants with ninaE¹⁷ the extra receptor cells do not degenerate, this implies the extra cells have an R7 or R8 identity. R7 specific gene expression determines the extra cells are receptor R7 cells. Ommatidia of double mutants with sev⁶ or boss¹ display extra R7 cells.

(Rogge et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

RasGAP1^sxt-BJ61 has visible phenotype, enhanceable by pb^hs.PB

(Boube et al., 1997)

Suppressed by

Statement

Reference

RasGAP1^sxt-BJ61, pb^hs.PB/pb[+] has visible phenotype, suppressible by Ras85D^e1B/Ras85D[+]

(Boube et al., 1997)

RasGAP1^sxt-BJ61, pb^hs.PB has visible phenotype, suppressible by Ras85D^e1B/Ras85D[+]

(Boube et al., 1997)

Enhancer of

Statement

Reference

RasGAP1^sxt-BJ61 is an enhancer of visible phenotype of pb^hs.PB

(Boube et al., 1997)

NOT Enhancer of

Statement

Reference

RasGAP1^sxt-BJ61/RasGAP1^sxt-BJ61 is a non-enhancer of chemical resistant phenotype of IP3K1^UY530, Scer\GAL4^da.G32

(Monnier et al., 2002)

NOT Suppressor of

Statement

Reference

RasGAP1^sxt-BJ61/RasGAP1^sxt-BJ61 is a non-suppressor of chemical resistant phenotype of IP3K1^UY530, Scer\GAL4^da.G32

(Monnier et al., 2002)

Other

Statement

Reference

Ras85D^e1B, RasGAP1^sxt-BJ61, pb^hs.PB/pb[+] has visible phenotype

(Boube et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

RasGAP1^sxt-BJ61 has wing vein phenotype, enhanceable by pb^hs.PB

(Boube et al., 1997)

Suppressed by

Statement

Reference

RasGAP1^sxt-BJ61, pb^hs.PB/pb[+] has antenna phenotype, suppressible by Ras85D^e1B/Ras85D[+]

(Boube et al., 1997)

RasGAP1^sxt-BJ61, pb^hs.PB/pb[+] has wing vein phenotype, suppressible by Ras85D^e1B/Ras85D[+]

(Boube et al., 1997)

Df(3R)Ubx109/+, RasGAP1^sxt-BJ61 has haltere phenotype, suppressible | partially by Ras85D^e1B/Ras85D[+]

(Boube et al., 1997)

RasGAP1^sxt-BJ61, pb^hs.PB has antenna phenotype, suppressible by Ras85D^e1B/Ras85D[+]

(Boube et al., 1997)

RasGAP1^sxt-BJ61, pb^hs.PB has wing vein phenotype, suppressible by Ras85D^e1B/Ras85D[+]

(Boube et al., 1997)

Enhancer of

Statement

Reference

RasGAP1^sxt-BJ61 is an enhancer of antenna phenotype of pb^hs.PB

(Boube et al., 1997)

RasGAP1^sxt-BJ61 is an enhancer of prothoracic tarsal segment 2 phenotype of scd¹

(Boube et al., 1997)

RasGAP1^sxt-BJ61 is an enhancer of sex comb phenotype of scd¹

(Boube et al., 1997)

Suppressor of

Statement

Reference

RasGAP1^sxt-BJ61 is a suppressor of labellum phenotype of pb⁴

(Boube et al., 1997)

Other

Statement

Reference

Ras85D^e1B, RasGAP1^sxt-BJ61, pb^hs.PB/pb[+] has wing vein phenotype

(Boube et al., 1997)

Ras85D^e1B, RasGAP1^sxt-BJ61, pb^hs.PB/pb[+] has antenna phenotype

(Boube et al., 1997)

Df(3R)Ubx109/+, Ras85D^e1B, RasGAP1^sxt-BJ61 has haltere phenotype

(Boube et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

The increased survival on medium containing 1% H₂O₂ of flies expressing IP3K1^UY530 under the control of Scer\GAL4^da.G32 is not altered if the flies are homozygous for Gap1^sxt-BJ61.

(Monnier et al., 2002)

The ectopic vein phenotype of Gap1^sxt-BJ61 homozygotes is enhanced by a copy of pb^hs.PB. This enhancement is reduced if the flies also carry one copy of Ras85D^e1B. One copy of Gap1^sxt-BJ61 has only a weak effect on the pb^hs.PB phenotype, but two copies of Gap1^sxt-BJ61 significantly enhance the antenna to maxillary transformation seen in pb^hs.PB flies. This enhancement is reduced if the flies also carry one copy of Ras85D^e1B. Alters the labial transformation phenotype of pb⁴ homozygotes towards wild-type. Enchances the scd¹/Y and Df(3R)Ubx109/+ phenotypes. The enhancement of the Df(3R)Ubx109/+ phenotype by Gap1^sxt-BJ61 is partially reversed if the flies also carry Ras85D^e1B.

(Boube et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Precise excision of the P-element reverts the mutant phenotype to wild type. Partial revertants have also been isolated.

(Rogge et al., 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Gap1^BJ61

(Monnier et al., 2002, Boube et al., 1997)

Gap1^sxt-BJ61

Gap1^sxt

(Kolodkin et al., 1994)

RasGAP1^sxt-BJ61

sxt^BJ61

(Rogge et al., 1992)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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