FlyBase Allele Report: Dmel\fz[HD21]

General Information

Symbol

Dmel\fz^HD21

Species

D. melanogaster

Name

FlyBase ID

FBal0039359

Feature type

allele

Associated gene

Dmel\fz

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Adler et al., 1994)

Progenitor genotype

Cytology

Description

Amino acid replacement: G485R.

(Povelones et al., 2005)

Missense mutation in a putative transmembrane domain. Amino acid replacement: G?R.

(Jones et al., 1996)

Amino acid replacement: G485R. Residue is in the middle of a highly hydrophobic stretch of amino acids that is predicted to be a transmembrane domain, prediction is that residue 485 is in the sixth transmembrane domain.

(Adler et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:14,366,987..14,366,987 [+]

Nucleotide change:

G14366987A

Amino acid change:

G485R | fz-PA; G485R | fz-PC

Reported amino acid change:

G?R

Comment:

Missense mutation in a putative transmembrane domain; position of mutation on reference sequence inferred from Figure 3.

(Jones et al., 1996)

point_mutation

3L:14,366,987..14,366,987 [+]

Nucleotide change:

G14366987A

Amino acid change:

G485R | fz-PA; G485R | fz-PC

Reported amino acid change:

G485R

Comment:

The mutant residue is in the middle of a highly hydrophobic stretch of amino acids that is predicted to be a sixth transmembrane domain. The position of the mutation on the reference sequence was inferred from Figure 3.

(Povelones et al., 2005, Adler et al., 1994)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | cold sensitive

(Adler et al., 1994)

visible | cold sensitive (with fz³⁰)

(Povelones et al., 2005)

Phenotype Manifest In

wing

(Jones et al., 1996)

wing | cold sensitive

(Adler et al., 1994)

wing hair | cold sensitive

(Adler et al., 1994)

wing hair | increased number | cold sensitive (with fz³⁰)

(Povelones et al., 2005)

Detailed Description

Statement

Reference

fz^HD21 has a moderate multiple wing hair phenotype in combination with fz³⁰ at 18^oC, and a weak multiple wing hair phenotype in combination with fz³⁰ at 25^oC.

(Povelones et al., 2005)

Non-autonomous phenotype in wing clones.

(Jones et al., 1996)

At the restrictive temperature 80% of the dorsal wing surface of hemizygous flies show grossly abnormal polarity. Phenotype is weaker at the permissive temperature. Temperature shift experiments demonstrate the severity of the effect of temperature on hair polarity is cumulative; the larger the fraction of the sensitive period at the restrictive temperature the more severe the phenotype. The cold sensitive period ends prior to the first visible sign of prehair formation.

(Adler et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

fz^HD21 is an enhancer of wing hair & 1st posterior cell phenotype of in^II53

(Lee and Adler, 2002)

Other

Statement

Reference

fz2^e2, fz^GL31/fz^HD21 has embryonic/first instar larval cuticle | maternal effect phenotype

(Povelones et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Embryos that lack zygotic fz and fz2 function which are derived from fz^HD21/fz^GL31 fz2^e2 females mated to fz^GL31 fz2^e2/+ males are modestly shortened and have mild patterning defects in the cuticle.

(Povelones et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

fz^HD21

fz^cs

(Adler et al., 1994)

Name Synonyms

cold sensitive

(Adler et al., 1994)

Secondary FlyBase IDs

References (6)

Report Sections

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