FB2026_02 , released June 18, 2026
Allele: Dmel\InR211
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General Information
Symbol
Dmel\InR211
Species
D. melanogaster
Name
FlyBase ID
FBal0042631
Feature type
allele
Associated gene
Dmel\InR
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Fernandez et al., 1995)
Mutagen
ethyl methanesulfonate
(Fernandez et al., 1995)
Progenitor genotype
Cytology
Description

Amino acid replacement: G1551R.

(Brogiolo et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:21,575,031..21,575,031 [-]
Nucleotide change:

G21575031M

Amino acid change:

G1599R | InR-PA; G1599R | InR-PB; G1599R | InR-PC; G1599R | InR-PD

Reported amino acid change:

G1551R

Comment:

Mutation is in cytoplasmic region. Specific nucleotide change unspecified; from G to either A or C

Comment:

Site of nucleic acid difference in mutant inferred by FlyBase based on reported amino acid change.

(Brogiolo et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      InR211/+ flies have an increased rate of stress-induced heart failure at five weeks compared to at one week, as occurs in wild-type flies. In contrast, InR211/InRE19 flies experience no increase in heart failure between the ages of one and five weeks. These flies also have a reduced decrease in heart rate compared to wild-type flies and a longer lifespan.

      (Wessells et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Alleles of InR form an allelic series based on phenotypic strength: InR339 > InR31 > InR211 > InRE19 > InR353.

      (Brogiolo et al., 2001)

      When in trans with Df(3R)e-D7 the lethal phenotype can be rescue by P{hs-inr}.

      (Fernandez et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      InR211
      (Yamamoto et al., 2021)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)