FlyBase Allele Report: Rnor\Map2[UAS.cAa]

General Information

Symbol

Rnor\Map2^UAS.cAa

Species

R. norvegicus

Name

Saccharomyces cerevisiae UAS construct a of Adam

FlyBase ID

FBal0042665

Feature type

allele

Associated gene

Rnor\Map2

Associated Insertion(s)

Carried in Construct

P{UAS-MAP2.A}

Transgenic product class

wild_type

(Adam, 1996.1.17)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Adam, 1996.1.17)

Mutagen

in vitro construct

(Adam, 1996.1.17)

Progenitor genotype

Carried in construct

P{UAS-MAP2.A}

Cytology

Description

UAS sequences direct the expression of Rnor\Map2 c-transcript coding region.

(Adam, 1996.1.17)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Rnor\Map2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^unspecified

(Warrick et al., 1999)

Phenotype Manifest In

eye, with Scer\GAL4^unspecified

(Warrick et al., 1999)

Detailed Description

Statement

Reference

Expression of Rnor\MAP2^Scer\UAS.cAa under the control of Scer\GAL4^unspecified produces a disrupted eye phenotype.

(Warrick et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Rnor\Map2^UAS.cAa, Scer\GAL4^unspecified has visible phenotype, non-suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^unspecified

(Warrick et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

Rnor\Map2^UAS.cAa, Scer\GAL4⁴⁴ has axon phenotype, enhanceable by futsch^EP1419, Scer\GAL4⁴⁴

(Hummel et al., 2000)

NOT suppressed by

Statement

Reference

Rnor\Map2^UAS.cAa, Scer\GAL4^unspecified has eye phenotype, non-suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^unspecified

(Warrick et al., 1999)

Enhancer of

Statement

Reference

Rnor\Map2^UAS.cAa, Scer\GAL4⁴⁴ is an enhancer of axon phenotype of Scer\GAL4⁴⁴, futsch^EP1419

(Hummel et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of futsch^EP1419 and Rnor\MAP2^Scer\UAS.cAa driven by Scer\GAL4⁴⁴ results in frequent axonal swellings and misprojection phenotypes. In 1/5 of neuromeres sensory neurons project their axons in on one of the two commissures across the central nervous system (CNS) midline and fasciculate with their contralateral counterparts, which they never do in wild-type.

(Hummel et al., 2000)

The disrupted eye phenotype produced by expression of Rnor\MAP2^Scer\UAS.cAa under the control of Scer\GAL4^unspecified is not modified by coexpression of Hsap\HSPA1L^Scer\UAS.cWa.

(Warrick et al., 1999)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

128

y¹ w¹¹¹⁸; P{UAS-MAP2.A}48C

Kyoto

105749