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Citation
Hummel, T., Krukkert, K., Roos, J., Davis, G., Klämbt, C. (2000). Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and axonal development.  Neuron 26(2): 357--370.
FlyBase ID
FBrf0128497
Publication Type
Research paper
Abstract

Here we report the description of the Drosophila gene futsch, which encodes a protein recognized by the monoclonal antibody 22C10 that has been widely used to visualize neuronal morphology and axonal projections. The Futsch protein is 5327 amino acids in length. It localizes to the microtubule compartment of the cell and associates with microtubules in vitro. The N- and C-terminal domains of Futsch are homologous to the vertebrate MAP1B microtubule-associated protein. The central domain of the Futsch protein is highly repetitive and shows sequence similarity to neurofilament proteins of which no Drosophila homologs have been reported. Loss-of-function analyses demonstrate that during embryogenesis Futsch is necessary for dendritic and axonal growth. Gain-of-function analyses demonstrate a functional interaction of Futsch with other MAPs. In addition, we show that during development, futsch expression is negatively regulated in nonneuronal tissues.

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PubMed Central ID
Related Publication(s)
Personal communication to FlyBase

ftz-GAL4 and 44-GAL4, and GAL4 line P0163.
Klämbt, 2000.8.16, ftz-GAL4 and 44-GAL4, and GAL4 line P0163. [FBrf0131019]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference
    Aberrations (6)
    Alleles (12)
    Genes (5)
    Insertions (4)
    Transgenic Constructs (3)
    Transcripts (2)