FlyBase Allele Report: Dmel\gbb[UAS.cSb]

General Information

Symbol

Dmel\gbb^UAS.cSb

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct b of Staehling-Hampton

FlyBase ID

FBal0042786

Feature type

allele

Associated gene

Dmel\gbb

Associated Insertion(s)

Carried in Construct

P{UAS-Tgfβ-60A.S2}

Also Known As

UAS-gbb

Key Links

Transgenic product class

cDNA

(Staehling-Hampton et al., 1994)

wild_type

(Staehling-Hampton et al., 1994)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Staehling-Hampton et al., 1994)

wild_type

(Staehling-Hampton et al., 1994)

Mutagen

in vitro construct

(Staehling-Hampton et al., 1994)

Progenitor genotype

Carried in construct

P{UAS-Tgfβ-60A.S2}

Cytology

Description

UASt regulatory sequences drive expression of a gbb cDNA, without an SV40 poly(A) signal.

(Staehling-Hampton et al., 1994)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

gbb

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of pupal stage, with Scer\GAL4^how-24B

(Staehling-Hampton et al., 1994)

some die during pupal stage, with Scer\GAL4^how-24B

(Staehling-Hampton et al., 1994)

visible, with Scer\GAL4^dpp.blk1

(Staehling-Hampton et al., 1994)

Phenotype Manifest In

wing, with Scer\GAL4^dpp.blk1

(Staehling-Hampton et al., 1994)

Detailed Description

Statement

Reference

Expression of P{GawB}69B causes pupal lethality, adult escapers exhibit a distinctive deflated wing phenotype. Expression of P{GAL4-dpp.blk1} causes wing blistering.

(Staehling-Hampton et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

gbb^UAS.cSb/Scer\GAL4^dpp.blk1 is a non-suppressor of eye phenotype of dpp^d-blk

(Staehling-Hampton et al., 1994)

gbb^UAS.cSb/Scer\GAL4^dpp.blk1 is a non-suppressor of eye phenotype of dpp^d6

(Staehling-Hampton et al., 1994)

gbb^UAS.cSb/Scer\GAL4^dpp.blk1 is a non-suppressor of wing phenotype of dpp^d6

(Staehling-Hampton et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to rescue

Scer\GAL4^unspecified/gbb^UAS.cSb fails to rescue gbb^unspecified

(Wharton, 2003.10.8)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

UAS-gbb lines that have the SV40 poly(A) signal produce weaker phenotypes than the lines with the signal removed, when crossed to different Scer\GAL4 lines. P{GAL4-dpp.blk1} driven expression of P{UAS-Tgfβ-60A.S1} or P{UAS-Tgfβ-60A.S2} is unable to rescue the mutant phenotype of dpp^d-blk or dpp^d6. gbb cannot substitute dpp function in the imaginal discs.

(Staehling-Hampton et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Tgfβ-60A^UAS.cSb

gbb^Scer\UAS.cSb

gbb^UAS.cSb

Name Synonyms

Saccharomyces cerevisiae UAS construct b of Staehling-Hampton

(Staehling-Hampton et al., 1994)

Secondary FlyBase IDs

References (7)

Report Sections

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