FlyBase Allele Report: Dmel\dpp[d-blk]

General Information

Symbol

Dmel\dpp^d-blk

Species

D. melanogaster

Name

FlyBase ID

FBal0002996

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

H{}dpp-d-blk

Carried in Construct

Also Known As

dpp^blk

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Blackman et al., 1987)

Progenitor genotype

Associated Insertion(s)

H{}dpp-d-blk

Cytology

Polytene chromosomes normal.

Description

Deletion from position 106 to 111.4 on the molecular map (FBrf0051824).

(Bergstrom et al., 1995)

5kb deletion of sequences 17kb 3' of the dpp transcribed region.

(Masucci et al., 1990)

Deletion spanning the disc region II and III, insertion of 1.9kb hobo element at the deletion site.

(Blackman et al., 1987)

hobo

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Jones et al., 2006, Bach et al., 2003, Lin et al., 2003, Treisman et al., 1997, Staehling-Hampton et al., 1994, Masucci et al., 1990, Blackman et al., 1987)

visible | recessive

(Curtiss and Mlodzik, 2000, Royet and Finkelstein, 1997)

Phenotype Manifest In

Detailed Description

Statement

Reference

Mutants have a very small, rough eye with few facets.

(Jones et al., 2006)

Homozygotes have small eyes.

(Bach et al., 2003)

Mutant show partial inhibition of the morphogenetic furrow, and reduced photoreceptor differentiation, resulting in a small eye phenotype in adults.

(Lin et al., 2003)

A morphogenetic furrow initiates only in the centre of mutant eye discs. Although it progresses anteriorly in a normal fashion, it fails to spread laterally. Homozygous flies have small eyes.

(Curtiss and Mlodzik, 2000)

Small, rough eyes.

(Horsfield et al., 1998)

Ommatidial array is slightly disorganised but an equator is still discernible separating 10 or more rows of dorsal ommatidia from 2-3 rows of ventral ommatidia. Head cuticle replaces portions of the retinal field near the dorsal and ventral margins (the effect is more pronounced ventrally). Rotational polarity is maintained in dorsal and ventral portions. Asymmetric retinal differentiation occurs with retinal development (failure of ommatidial differentiation in the ventral eye disc), it is not a consequence of cell death. Anterior-dorsal ptc^S2 clone in dpp^d-blk eye disc causes ectopic differentiation ahead of the morphogenetic furrow, this wave of ectopic differentiation propogates into neighbouring ptc⁺ tissue. A ventral margin clone in dpp^d-blk eye disc causes ectopic differentiation that propogates into ventral ptc⁺ tissue. Clone spanning a large portion of ventral epithelium and ventral posterior margin rescues ventral differentiation to a relatively normal pattern.

(Chanut and Heberlein, 1997)

dally⁰⁶⁴⁶⁴ homozygotes show a slight reduction in the eye which is more severe when they are also heterozygous for dpp^d-blk.

(Jackson et al., 1997)

Homozygotes have greatly reduced compound eyes consisting of only a few ommatidia. The eye is largely replaced by frons cuticle, with ectopic frons cuticle lying between the orbital cuticle and the remaining ommatidia, and also between the shingle cuticle and ommatidia.

(Royet and Finkelstein, 1997)

Small eye phenotype.

(Treisman et al., 1997, Staehling-Hampton et al., 1994)

Eye discs have a similar appearance to those of hypomorphic Mad alleles. The furrow initiates in a restricted area at the posterior edge and dpp expression is not maintained along the posterior margin.

(Wiersdorff et al., 1996)

Allows furrow movement only in the central region of the eye disc, loss of one copy of wg is sufficient to increase the size of the eye.

(Treisman and Rubin, 1995)

Reduction in number of eye facets. Mutant phenotype can be rescued by P{TnJMB7}.

(Masucci et al., 1990)

Eye reduced in size.

(Blackman et al., 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dpp^d-blk has visible | recessive phenotype, enhanceable by so^UAS.cPa/Scer\GAL4^dpp.blk1

(Curtiss and Mlodzik, 2000)

dpp^d-blk has visible | recessive phenotype, enhanceable by so^UAS.cPa/Scer\GAL4^ey.PH

(Curtiss and Mlodzik, 2000)

dpp^d-blk has visible | recessive phenotype, enhanceable by Scer\GAL4^ey.PH/dac^UAS.cSa

(Curtiss and Mlodzik, 2000)

dpp^d-blk has visible | recessive phenotype, enhanceable by ey^UAS.cHa/Scer\GAL4^ey.PH

(Curtiss and Mlodzik, 2000)

Suppressed by

Statement

Reference

dpp^d-blk has visible phenotype, suppressible by l(2)rQ313[+]/snama^rQ313

(Jones et al., 2006)

dpp^d-blk has visible phenotype, suppressible by snama^PX1/mnm[+]

(Jones et al., 2006)

dpp^d-blk has visible phenotype, suppressible by spen^k13624/spen^k07721

(Lin et al., 2003)

dpp^d-blk has visible | recessive phenotype, suppressible by Scer\GAL4^dpp.blk1/eya^UAS.cBa

(Curtiss and Mlodzik, 2000)

Enhancer of

Statement

Reference

dpp^d-blk/dpp[+] is an enhancer of visible | recessive phenotype of dally⁰⁶⁴⁶⁴

(Jackson et al., 1997)

Other

Statement

Reference

dally⁰⁶⁴⁶⁴, dpp^d-blk/dpp[+] has visible | dominant phenotype

(Jackson et al., 1997)

dally[+]/dally⁰⁶⁴⁶⁴, dpp^d-blk has visible | dominant phenotype

(Jackson et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

dpp^d-blk has eye phenotype, enhanceable by trr¹/trr[+]

(Sedkov et al., 2003)

dpp^d-blk has eye phenotype, enhanceable by B[+]/Bar¹

(Sedkov et al., 2003)

dpp^d-blk has eye phenotype, enhanceable by ey^UAS.cHa/Scer\GAL4^ey.PH

(Curtiss and Mlodzik, 2000)

dpp^d-blk has eye phenotype, enhanceable by so^UAS.cPa/Scer\GAL4^dpp.blk1

(Curtiss and Mlodzik, 2000)

dpp^d-blk has eye phenotype, enhanceable by so^UAS.cPa/Scer\GAL4^ey.PH

(Curtiss and Mlodzik, 2000)

dpp^d-blk has eye phenotype, enhanceable by Scer\GAL4^ey.PH/dac^UAS.cSa

(Curtiss and Mlodzik, 2000)

dpp^d-blk has eye phenotype, enhanceable by osa³⁰⁸

(Treisman et al., 1997)

Suppressed by

Statement

Reference

dpp^d-blk has eye phenotype, suppressible by l(2)rQ313[+]/snama^rQ313

(Jones et al., 2006)

dpp^d-blk has eye phenotype, suppressible by snama^PX1/mnm[+]

(Jones et al., 2006)

dpp^d-blk has ommatidium phenotype, suppressible by l(2)rQ313[+]/snama^rQ313

(Jones et al., 2006)

dpp^d-blk has ommatidium phenotype, suppressible by snama^PX1/mnm[+]

(Jones et al., 2006)

dpp^d-blk has eye phenotype, suppressible by spen^k13624/spen^k07721

(Lin et al., 2003)

dpp^d-blk has photoreceptor neuron phenotype, suppressible by spen^k13624/spen^k07721

(Lin et al., 2003)

dpp^d-blk has eye phenotype, suppressible by Scer\GAL4^dpp.blk1/eya^UAS.cBa

(Curtiss and Mlodzik, 2000)

dpp^d-blk has eye disc morphogenetic furrow phenotype, suppressible by Scer\GAL4^dpp.blk1/eya^UAS.cBa

(Curtiss and Mlodzik, 2000)

dpp^d-blk has eye disc phenotype, suppressible by Scer\GAL4^dpp.blk1/eya^UAS.cBa

(Curtiss and Mlodzik, 2000)

dpp^d-blk has ommatidium phenotype, suppressible by Scer\GAL4^dpp.blk1/eya^UAS.cBa

(Curtiss and Mlodzik, 2000)

dpp^d-blk has eye-antennal disc phenotype, suppressible by Mad^{Ubi-p63E.Tag:MYC}

(Wiersdorff et al., 1996)

NOT suppressed by

Statement

Reference

dpp^d-blk has eye phenotype, non-suppressible by gbb^UAS.cSa/Scer\GAL4^dpp.blk1

(Staehling-Hampton et al., 1994)

dpp^d-blk has eye phenotype, non-suppressible by gbb^UAS.cSb/Scer\GAL4^dpp.blk1

(Staehling-Hampton et al., 1994)

Enhancer of

Statement

Reference

dpp^d-blk/dpp[+] is an enhancer of eye phenotype of dally⁰⁶⁴⁶⁴

(Jackson et al., 1997)

Suppressor of

Statement

Reference

dpp^d-blk is a suppressor of phenotype of wg^l-12

(Treisman and Rubin, 1995)

Other

Statement

Reference

dally[+]/dally⁰⁶⁴⁶⁴, dpp^d-blk has eye phenotype

(Jackson et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

The dpp^d-blk phenotype is partially rescued by eya^Scer\UAS.cBa expressed under the control of Scer\GAL4^dpp.blk1. Specifically, the morphogenetic furrow spreads in a normal fashion dorsally along the lateral margin to form an almost complete dorsal half of an eye. The morphogenetic furrow does not spread ventrally along the margin. The small size of dpp^d-blk/dpp^d12 eye discs is partially rescued by eya^Scer\UAS.cBa expressed under the control of Scer\GAL4^dpp.blk1 and greater numbers of developing ommatidia are seen. The dpp^d-blk small eye phenotype is enhanced by so^Scer\UAS.cPa expressed under the control of either Scer\GAL4^dpp.blk1 or Scer\GAL4^ey.PH, which often results in a complete lack of eye development. Expression of dac^Scer\UAS.cSa under the control of Scer\GAL4^ey.PH results in a variable decrease in the size of dpp^d-blk eyes. Expression of ey^Scer\UAS.cHa under the control of Scer\GAL4^ey.PH interferes with dpp^d-blk eye development to a variable extent, often resulting in smaller eyes.

(Curtiss and Mlodzik, 2000)

Flies heterozygous for both dally⁰⁶⁴⁶⁴ and dpp^d-blk show eye abnormalities never observed in flies heterozygous for dally⁰⁶⁴⁶⁴ or dpp^d-blk alone.

(Jackson et al., 1997)

The eye disc phenotype is partially rescued by Mad^{Ubi-p63E.T:Hsap\MYC}.

(Wiersdorff et al., 1996)

In wg^l-12, dpp^d-blk eye discs the dpp^d-blk mutation completely abolishes the effects of loss of wg expression (inwardly directed furrow movement is not present).

(Treisman and Rubin, 1995)

In double mutants of bun^rI043 and the eye specific allele dpp^d-blk the frequency of survivors is decreased relative to the single bun^rI043 mutant and the eye is extremely reduced due to differentiation of a very small number of ommatidia.

(Treisman et al., 1995)

Scer\GAL4^dpp.blk1 driven expression of gbb^Scer\UAS.cSb or gbb^Scer\UAS.cSa is unable to rescue the mutant phenotype.

(Staehling-Hampton et al., 1994)

Transheterozygotes with eya⁴ are normal.

(Eissenberg and Ryerse, 1991)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

dpp^d-blk is rescued by dpp^UAS.cSa/Scer\GAL4^dpp.blk1

(Staehling-Hampton et al., 1994)

Comments

Small eye phenotype can be rescued by dpp^TnJMB7 and Scer\GAL4^dpp.blk1 driving the expression of dpp^Scer\UAS.cSa.

(Staehling-Hampton et al., 1994)

Allele class: d-blk

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

The strain dpp^d-blk is capable of promoting the mobilization of hobos. The strain contains numerous internally deleted hobos and two 3.0kb copies. The ability to promoter mobilisation results from the action of the 3.0kb elements. One of these elements was cloned and used to produce plasmid "pHFL1".

(Blackman et al., 1989)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

dpp^blk

(Jones et al., 2006, Bach et al., 2003, Lin et al., 2003, Sedkov et al., 2003, Chanut et al., 2002, Lin et al., 2001, Curtiss and Mlodzik, 2000, Greenwood and Struhl, 1999, Chanut and Heberlein, 1997, Chanut and Heberlein, 1997, Fini et al., 1997, Heldin et al., 1997, Jackson et al., 1997, Liu and Reinke, 1997, Theisen et al., 1996, Wiersdorff et al., 1996, Eissenberg and Ryerse, 1991, Blackman et al., 1987)

dpp^d-blk

(Won et al., 2015)

dpp^dblk

(Calvi and Gelbart, 1994)

Name Synonyms

blink

(Theisen et al., 1996)

Secondary FlyBase IDs

References (33)

Report Sections

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