FlyBase Allele Report: Dmel\snama[rQ313]

General Information

Symbol

Dmel\snama^rQ313

Species

D. melanogaster

Name

FlyBase ID

FBal0101300

Feature type

allele

Associated gene

Dmel\snama

Associated Insertion(s)

P{PZ}snama^rQ313

Carried in Construct

Also Known As

l(2)rQ313^rQ313

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Spradling et al., 1999)

Progenitor genotype

Associated Insertion(s)

P{PZ}snama^rQ313

Cytology

Description

Insertion in the first intron.

(Jones et al., 2006)

P{PZ} insertion in the first intron.

(Mather et al., 2005)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:24,087,324..24,087,324 [-]

(Jones et al., 2006, Mather et al., 2005, Spradling et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death

(Mather et al., 2005)

lethal | recessive

(Mather et al., 2005, Spradling et al., 1999)

lethal - all die during embryonic stage | recessive

(Jones et al., 2006)

some die during embryonic stage | recessive

(Jones et al., 2006)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous clones in the eye (induced using the "eyFLP" method) are large and occupy roughly half of the eye (as seen for control clones). Both wild-type and mutant clones contain mutant photoreceptor cells.

(Jones et al., 2006)

Late stage mutant embryos show ectopic apoptosis compared to wild-type embryos. Mutant embryos show early occurrence of apoptosis in the blastoderm, which is not seen in wild-type embryos.

(Mather et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

l(2)rQ313[+]/snama^rQ313 is an enhancer of visible phenotype of hh^bar3/hh⁸

(Jones et al., 2006)

Suppressor of

Statement

Reference

l(2)rQ313[+]/snama^rQ313 is a suppressor of visible phenotype of N^spl-1

(Jones et al., 2006)

l(2)rQ313[+]/snama^rQ313 is a suppressor of visible phenotype of dpp^d-blk

(Jones et al., 2006)

Phenotype Manifest In

Enhancer of

Statement

Reference

l(2)rQ313[+]/snama^rQ313 is an enhancer of eye phenotype of hh^bar3/hh⁸

(Jones et al., 2006)

l(2)rQ313[+]/snama^rQ313 is an enhancer of ommatidium phenotype of hh^bar3/hh⁸

(Jones et al., 2006)

Suppressor of

Statement

Reference

l(2)rQ313[+]/snama^rQ313 is a suppressor of eye phenotype of N^spl-1

(Jones et al., 2006)

l(2)rQ313[+]/snama^rQ313 is a suppressor of ommatidium phenotype of N^spl-1

(Jones et al., 2006)

l(2)rQ313[+]/snama^rQ313 is a suppressor of eye phenotype of dpp^d-blk

(Jones et al., 2006)

l(2)rQ313[+]/snama^rQ313 is a suppressor of ommatidium phenotype of dpp^d-blk

(Jones et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

snama¹

(Jones et al., 2006)

Rescued by

snama^rQ313 is rescued by snama^+t14.7

(Jones et al., 2006)

Not rescued by

snama¹/snama^rQ313 is not rescued by snama^tmut4

(Jones et al., 2006)

snama^rQ313/snama^PX1 is not rescued by snama^tmut4

(Jones et al., 2006)

snama^rQ313 is not rescued by snama^tmut4

(Jones et al., 2006)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Complements: eIF-5A⁰¹²⁹⁶. Complements: gek⁰⁹³⁷³. Complements: Nop60B^k05318.

(BDGP Project Members, 1994-1999)

Precise excision of the insertion reverts the lethal phenotype.

(Jones et al., 2006)

Precise excision of the insertion reverts the abnormal apoptosis phenotype seen in mutant embryos.

(Mather et al., 2005)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

l(2)rQ313

(Spradling et al., 1999)

l(2)rQ313^rQ313

(Jones et al., 2006, Mather et al., 2005)

mnm^P

(Jones et al., 2006)

mnm^rQ313

snama^rQ313

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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