FB2026_02 , released June 18, 2026
Allele: Dmel\crbextra.UAS
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General Information
Symbol
Dmel\crbextra.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0042948
Feature type
allele
Associated gene
Dmel\crb
Associated Insertion(s)
Carried in Construct
P{UAS-crb.extra}
Also Known As
UAS-crbextra
Key Links
Transgenic product class
inframe_deletion
(Wodarz et al., 1995)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Wodarz et al., 1995)
Mutagen
in vitro construct
(Wodarz et al., 1995)
Progenitor genotype
Carried in construct
P{UAS-crb.extra}
Cytology
Description

UASt regulatory sequences drive expression of a secreted version of crb that lacks the transmembrane and cytoplasmic domains (the N-terminal signal peptide is still present).

(Wodarz et al., 1995)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
crb
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of crbextra.UAS under the control of Scer\GAL4GMR.long leads to a decrease in the ratio of pale vs yellow photoreceptor cells R8.

      (Pojer et al., 2021)

      Expression of crbextra.Scer\UAS under the control of Scer\GAL4ey.PH fails to rescue the crb11A22 head overgrowth phenotype.

      (Richardson and Pichaud, 2010)

      Over-expression of crbextra.Scer\UAS causes reduction of the photoreceptor cell stalk membrane.

      (Pellikka et al., 2002)

      Overexpression of crbextra.Scer\UAS, even at very high levels, has no consequence for epithelial development, viability or fertility of embryos, larvae or adults. The crb loss of function phenotype is not rescued at all by crbextra.Scer\UAS.

      (Wodarz et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav.PU/crbextra.UAS rescues crb11A22

      (Richard et al., 2009)
      Fails to rescue

      Scer\GAL4ey.PH/crbextra.UAS fails to rescue crb11A22

      (Richardson and Pichaud, 2010)

      Scer\GAL4elav.PU/crbextra.UAS fails to rescue crb11A22

      (Richard et al., 2009)
      Comments

      Expression of crbextra.Scer\UAS under the control of Scer\GAL4ey.PH fails to rescue the crb11A22 head overgrowth phenotype.

      (Richardson and Pichaud, 2010)

      Scer\GAL4elav.PU-mediated expression of crbextra.Scer\UAS nearly completely restores the overall morphology of crb11A22 photoreceptor cells.

      Scer\GAL4elav.PU-mediated expression of crbextra.Scer\UAS does not restore (has no effect on) the length of the stalk membrane in crb11A22 photoreceptor cells.

      (Richard et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      crbextra.Scer\UAS
      crbextra.UAS
      crbextra
      (Wodarz et al., 1995)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)