FlyBase Allele Report: Dmel\esc[unspecified]

General Information

Symbol

Dmel\esc^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0043048

Feature type

allele

Associated gene

Dmel\esc

Associated Insertion(s)

Carried in Construct

Also Known As

unspecified

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | recessive

(Hilliker and Holm, 1975)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous embryos derived from homozygous mothers develop into embryos which have a transformation of at least one cephalic segment (possibly the antennal segment) and two gnathal segments (possibly the labial and maxillary segments), all three thoracic segments and the first nine abdominal segments into segments variably resembling the wild-type eighth abdominal segment. Remnants of most of the normal head structures can usually be identified. Transformation of the cephalic, gnathal and ninth abdominal segments to the wild-type abdominal segment A8 is incomplete; none of these segments have posterior spiracles or sensory organs characteristic of A8. The antennal segment has a band of ventral-type hairs similar to A8, although they are located in the dorsal side of the head, suggesting that the transformed segment may have rotated. The labial, maxillary and ninth abdominal segment have ventral hairs ranging from a small tuft of hairs to three to five rows arranged in a square pattern. Homozygous embryos (derived from homozygous mothers) carrying only one copy of the bithorax complex show a less extreme transformation than those carrying the normal two copies of the bithorax complex, while those embryos carrying four copies of the bithorax complex show a more extreme transformation. Homozygous embryos (derived from homozygous mothers) carrying only one copy of Pc⁺ show a more complete transformation towards the eighth abdominal segment than those carrying the normal two copies of Pc⁺, while homozygous embryos (derived from homozygous mothers) that are also homozygous for Pc² show a more extreme transformation. Homozygous embryos (derived from homozygous mothers) carrying four copies of Pc⁺ are indistinguishable from embryos carrying the normal two copies of Pc⁺. Homozygous esc^unspecified embryos (derived from homozygous esc^unspecified mothers) that lack Scr⁺ are identical to homozygous esc^unspecified embryos (derived from homozygous esc^unspecified mothers) except that the labial pits are absent and are replaced by a second pair of maxillary sense organs, and the small tuft of ventral hairs associated with the labial pits are enlarged to form a square band of three to five rows of hairs.