FB2026_02 , released June 18, 2026
Allele: Dmel\hoipk07104
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General Information
Symbol
Dmel\hoipk07104
Species
D. melanogaster
Name
FlyBase ID
FBal0043122
Feature type
allele
Associated gene
Dmel\hoip
Associated Insertion(s)
P{lacW}hoipk07104
Carried in Construct
Also Known As
l(2)k07104
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Kania et al., 1995)
Progenitor genotype
Associated Insertion(s)
P{lacW}hoipk07104
Cytology
Description

P{lacW} insertion approximately 31bp upstream of the 5' end of the hoip GH03082 cDNA.

(Prokopenko et al., 2000)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AF175919
AF175920
AF175921
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  autosomal dominant cerebellar ataxia
      modeled by Hsap\ATXN8OSCTG112.UAS
      (Mutsuddi et al., 2004)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Somatic muscle morphology is aberrant in hoip1/hoipk07104 mutant embryos compared to wild type. In particular, the lateral transverse (LT1-4), lateral longitudinal (LL1), lateral oblique (LO1) and dorsal oblique (DO3-5) remain rounded rather than showing pronounced membrane extensions towards target sites as in wild type. Embryos fail to emerge from the chorion after embryogenesis. No PNS defects are detected.

      (Johnson et al., 2013)

      Homozygous embryos exhibit subtle organisation defects characterised by slightly misplaced cells within specific clusters. Embryos frequently exhibit mild fasciculation defects.

      (Kania et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      hoip[+]/hoipk07104 is an enhancer of abnormal neuroanatomy phenotype of Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF

      (Mutsuddi et al., 2004)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      I. Kiss.

      Comments
      Comments

      Complements: Pka-C101272.

      (Prokopenko et al., 2000)

      Complements: Pka-C101272. Complements: Pka-C1k08008. Complements: Pka-C1k08918. Complements: Pka-C1k16718. Complements: Pka-C1s4402.

      (BDGP Project Members, 1994-1999)

      Lethality not revertible with excision of the P{lacW} insert.

      (Kania et al., 1995)
      External Crossreferences and Linkouts ( 3 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      71/4
      (Kania et al., 1995)
      hoipk07104
      (Kahsai and Cook, 2018, Sofola et al., 2007)
      l(2)k07104
      (Mutsuddi et al., 2004, Prokopenko et al., 2000, Spradling et al., 1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)