FlyBase Allele Report: Dmel\bur[k07130]

General Information

Symbol

Dmel\bur^k07130

Species

D. melanogaster

Name

FlyBase ID

FBal0043487

Feature type

allele

Associated gene

Dmel\bur

Associated Insertion(s)

P{lacW}bur^k07130

Carried in Construct

Also Known As

Gmps^K07130, l(2)k07130

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{lacW}bur^k07130

Cytology

Description

Insertion in the first exon, 35bp downstream of the putative transcription start site.

(Long et al., 2006)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:21,179,662..21,179,662

(Long et al., 2006, Spradling et al., 1999, Neufeld et al., 1998, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Long et al., 2006)

lethal

(van der Knaap et al., 2005)

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Phenotype Manifest In

lamina

(Long et al., 2006)

medulla

(Long et al., 2006)

photoreceptor cell & axon

(Long et al., 2006)

photoreceptor cell & axon | somatic clone | cell autonomous

(Long et al., 2006)

photoreceptor cell R7 & growth cone

(Long et al., 2006)

photoreceptor cell R8 & growth cone

(Long et al., 2006)

Detailed Description

Statement

Reference

R-cell axons migrate properly towards the posterior end of the eye disc and enter the optic stalk normally in homozygous larvae, and the axon tract in the optic stalk is morphologically indistinguishable from wild type. However, after exiting the optic stalk, the mutant R-cell axons fail to maintain their normal neighbour relationships, resulting in abnormally thick bundles in the lamina and medulla, crossing over of neighbouring axon bundles in the medulla and a less organised array of R7 and R8 growth cones in the medulla compared to wild type. The R7 and R8 growth cones are less expanded than normal and have abnormal morphology.

Homozygous R-cell axons induced by the MARCM system in a heterozygous background do not expand upon reaching the target region in the optic lobe in 89% of cases and 16% have an abnormal topographic projection pattern.

(Long et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

bur[+]/bur^k07130 is an enhancer of visible phenotype of Usp7^Δ35

(van der Knaap et al., 2010)

bur[+]/bur^k07130 is an enhancer of visible | homeotic phenotype of Pc¹

(van der Knaap et al., 2005)

bur[+]/bur^k07130 is an enhancer of visible | recessive | homeotic phenotype of Pc³

(van der Knaap et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

bur[+]/bur^k07130 is an enhancer of wing phenotype of Usp7^Δ35

(van der Knaap et al., 2010)

bur[+]/bur^k07130 is an enhancer of abdominal segment 4 | male phenotype of Pc¹

(van der Knaap et al., 2005)

bur[+]/bur^k07130 is an enhancer of abdominal segment 5 | ectopic phenotype of Pc³

(van der Knaap et al., 2005)

bur[+]/bur^k07130 is an enhancer of haltere | ectopic | female phenotype of Pc³

(van der Knaap et al., 2005)

bur[+]/bur^k07130 is an enhancer of haltere | ectopic phenotype of Pc³

(van der Knaap et al., 2005)

bur[+]/bur^k07130 is an enhancer of prothoracic leg | ectopic | male phenotype of Pc³

(van der Knaap et al., 2005)

bur[+]/bur^k07130 is an enhancer of sex comb | ectopic | male phenotype of Pc³

(van der Knaap et al., 2005)

bur[+]/bur^k07130 is an enhancer of sex comb | ectopic phenotype of Pc³

(van der Knaap et al., 2005)

bur[+]/bur^k07130 is an enhancer of wing | female phenotype of Pc³

(van der Knaap et al., 2005)

bur[+]/bur^k07130 is an enhancer of abdominal segment 5 | ectopic | male phenotype of Pc¹

(van der Knaap et al., 2005)

bur[+]/bur^k07130 is an enhancer of haltere | ectopic phenotype of Pc¹

(van der Knaap et al., 2005)

bur[+]/bur^k07130 is an enhancer of prothoracic leg | ectopic | male phenotype of Pc¹

(van der Knaap et al., 2005)

bur[+]/bur^k07130 is an enhancer of sex comb | ectopic | male phenotype of Pc¹

(van der Knaap et al., 2005)

bur[+]/bur^k07130 is an enhancer of wing phenotype of Pc¹

(van der Knaap et al., 2005)

bur[+]/bur^k07130 is an enhancer of abdominal segment 4 | male phenotype of Pc³

(van der Knaap et al., 2005)

bur[+]/bur^k07130 is an enhancer of abdominal segment 5 | ectopic | male phenotype of Pc³

(van der Knaap et al., 2005)

Suppressor of

Statement

Reference

bur[+]/bur^k07130 is a suppressor of mesothoracic leg phenotype of Pc¹

(van der Knaap et al., 2005)

bur[+]/bur^k07130 is a suppressor of abdominal segment 4 phenotype of Pc³

(van der Knaap et al., 2005)

bur[+]/bur^k07130 is a suppressor of mesothoracic leg phenotype of Pc³

(van der Knaap et al., 2005)

bur[+]/bur^k07130 is a suppressor of wing phenotype of Pc³

(van der Knaap et al., 2005)

Other

Statement

Reference

Pc³, bur[+]/bur^k07130 has wing | male phenotype

(van der Knaap et al., 2005)

Pc³, bur[+]/bur^k07130 has antenna | female phenotype

(van der Knaap et al., 2005)

Pc³, bur[+]/bur^k07130 has haltere | ectopic | male phenotype

(van der Knaap et al., 2005)

Pc³, bur[+]/bur^k07130 has leg | ectopic | female phenotype

(van der Knaap et al., 2005)

Pc³, bur^k07130 has wing | male phenotype

(van der Knaap et al., 2005)

Pc³, bur^k07130 has antenna | female phenotype

(van der Knaap et al., 2005)

Pc³, bur^k07130 has haltere | ectopic | male phenotype

(van der Knaap et al., 2005)

Pc³, bur^k07130 has leg | ectopic | female phenotype

(van der Knaap et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity for bur^k07130 enhances the "held-out wing" phenotype of Usp7^Δ35 hemizygotes.

(van der Knaap et al., 2010)

Flies transheterozygous for bur^k07130 and Pc¹ or Pc³ exhibit very strong wing-to-haltere transformations. In addition, males transheterozygous for bur^k07130 and either Pc¹ or Pc³ also show partial transformation of the anterior abdominal segments A4 towards A5 and carry sex combs on the second legs.

(van der Knaap et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

bur^unspecified

(Neufeld et al., 1998)

bur¹⁰⁵²³

(BDGP Project Members, 1994-1999)

Comments

Images (0)