FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\phylsev.PC
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General Information
Symbol
Dmel\phylsev.PC
Species
D. melanogaster
Name
sevenless promoter construct of Chang
FlyBase ID
FBal0044271
Feature type
allele
Associated gene
Dmel\phyl
Associated Insertion(s)
Carried in Construct
P{sev-phyl.C}
Also Known As
sev-phyl
Key Links
Transgenic product class
cDNA
(Chang et al., 1995)
wild_type
(Chang et al., 1995)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Chang et al., 1995)
wild_type
(Chang et al., 1995)
Mutagen
in vitro construct
(Chang et al., 1995)
Progenitor genotype
Carried in construct
P{sev-phyl.C}
Cytology
Description

sev regulatory sequences drive expression of the phyl coding sequence (derived from cDNA).

(Chang et al., 1995)
Allele components
Component
Use(s)
Regulatory region(s)
sev
Encoded product / tool
phyl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies bearing one copy of phylsev.PC have rough eyes. Ommatidia are disorganised and have multiple defects, the predominant one (approximately 39% of ommatidia) being the generation of extra R7-like cells with small rhabdomeres. Phenotype is similar to that produced by activation of the Ras pathway. Phenotype is dependent on sina but independent of sev.

      (Chang et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      phylsev.PC, sevS11.Tag:MYC has viable phenotype

      (Maixner et al., 1998)
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      phylsev.PC has phenotype, non-enhanceable by lilliXS407

      (Tang et al., 2001)

      phylsev.PC has phenotype, non-enhanceable by lilliXS575

      (Tang et al., 2001)

      phylsev.PC has phenotype, non-enhanceable by lillis35

      (Tang et al., 2001)
      NOT suppressed by
      Statement
      Reference

      phylsev.PC has phenotype, non-suppressible by lilliXS407

      (Tang et al., 2001)

      phylsev.PC has phenotype, non-suppressible by lillis35

      (Tang et al., 2001)

      phylsev.PC has phenotype, non-suppressible by lilliXS575

      (Tang et al., 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Not lethal in combination with sevS11.T:Hsap\MYC.

      (Maixner et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      sev regulatory sequences are active in R3, R4, R7, the cone cell precursors, the mystery cells and, at lower levels in R1 and R6.

      (Chang et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      phylsev.PC
      Name Synonyms
      sevenless promoter construct of Chang
      (Chang et al., 1995)
      Secondary FlyBase IDs
        References (4)