FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\NrtM100
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General Information
Symbol
Dmel\NrtM100
Species
D. melanogaster
Name
FlyBase ID
FBal0044721
Feature type
allele
Associated gene
Dmel\Nrt
Associated Insertion(s)
Carried in Construct
Also Known As
dabM100
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
(Hill et al., 1995)
ethyl methanesulfonate
(Liebl et al., 2003, Hill et al., 1995)
Progenitor genotype
Cytology
Description

Amino acid replacement: V542D.

(Liebl et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:16,775,444..16,775,444 [+]
Nucleotide change:

T16775444A

Amino acid change:

V542D | Nrt-PA; V542D | Nrt-PB; V542D | Nrt-PC

Reported amino acid change:

V542D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Liebl et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones in the eye have abnormal ommatidia which often lack the R7 photoreceptor cell and sometimes lack one or more outer photoreceptors. Large clones show ommatidial disorganisation, including regions where no photoreceptors are present.

      (Le and Simon, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Abl4/Abl1, NrtM100 has abnormal neuroanatomy phenotype

      (Liebl et al., 2003)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      36% of segments have commissure defects in the central nervous system of Abl1 NrtM100/Abl4 embryos.

      (Liebl et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Induced on: Abl1. The NrtM100 mutant allele was originally thought to be a mutation in the Dab gene (see FBrf0049327, FBrf0058531 and FBrf0084025), but sequencing of the chromosome indicates that it is a lesion in the Nrt gene.

      (Liebl et al., 2003)
      Comments
      Comments

      "X ray" was stated as tentative. "ethyl methanesulfonate" was stated as tentative. Haploinsufficiency dependent upon an Abl mutant background (HDA).

      (Hill et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Dabm100
      NrtM100
      dab100
      (Le and Simon, 1998)
      dabM100
      (Liebl et al., 2003, Hill et al., 1995)
      nrtM100
      (Liebl et al., 2003)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)