FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Med2
Open Close
General Information
Symbol
Dmel\Med2
Species
D. melanogaster
Name
FlyBase ID
FBal0044929
Feature type
allele
Associated gene
Dmel\Med
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Raftery et al., 1995)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous embryos derived from females with homozygous germ line clones have fully ventralised cuticles. Med2/Med4 embryos show a partial loss of the second midgut constriction. Homozygous clones in the wing pouch do not survive when induced during the first larval instar stage, although clones are recovered elsewhere in the wing disk. Homozygous clones of variable size are recovered in the wing pouch when induced in the middle of the second larval instar stage (66 hours before pupariation).

      (Wisotzkey et al., 1998)

      Homozygous third larval instar have variably reduced central nervous systems.

      (Raftery et al., 1995)

      Lethality occurs during larval and pupal stages.

      (Raftery, 1995.4.6)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Med2 is an enhancer of phenotype of dpphr4

      (Raftery et al., 1995)
      Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The combination Med2/Med4 usually restores the first and third midgut constrictions in embryos expressing dppScer\UAS.cSa under the control of Scer\GAL4how-24B.

      (Wisotzkey et al., 1998)

      Maternal lethal interaction with dpphr4 is due to a loss of dorsal-most fates in the embryos, demonstrated by loss of amnioserosa cells. dpphr4/dpp+;Med2/Med+ embryos have a partially involuted head skeleton. Embryos exhibits a 'tail up' phenotype, the posterior most structures are pointed more vertically and there is more curvature to the abdominal segments.

      (Raftery et al., 1995)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Med2
      Name Synonyms
      Secondary FlyBase IDs
        References (5)