FlyBase Allele Report: Dmel\Med[4]

General Information

Symbol

Dmel\Med⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0044931

Feature type

allele

Associated gene

Dmel\Med

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Yoshida et al., 2005)

Mutagen

ethyl methanesulfonate

(Raftery et al., 1995)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Chen et al., 1998, Raftery, 1995.4.6)

lethal - all die before end of pupal stage | recessive

(Raftery et al., 1995)

some die during pupal stage | recessive

(Raftery et al., 1995)

Phenotype Manifest In

embryonic/larval midgut | embryonic stage

(Wisotzkey et al., 1998)

embryonic midgut constriction 2

(Wisotzkey et al., 1998)

eye photoreceptor cell stalk | somatic clone

(Yoshida et al., 2005)

gastric caecum

(Wisotzkey et al., 1998)

lamina | somatic clone

(Yoshida et al., 2005)

larval central nervous system

(Raftery et al., 1995)

Detailed Description

Statement

Reference

Med⁴ mutants exhibit defects in R axon projection and lamina morphology. Such defects are only observed when large clones are generated in the posterior-dorsal or ventral domains, which presumably include glial cell progenitors. Clones in other regions, such as the outer proliferation center, lamina or medulla, do not result in R-axon targeting defects.

(Yoshida et al., 2005)

Lethal in transheterozygous combination with Med^D5.

(Chen et al., 1998)

Med⁴/Df(3R)Kpn-A embryos sometimes have abnormal gastric caeca and midgut morphology. Med²/Med⁴ embryos show a partial loss of the second midgut constriction.

(Wisotzkey et al., 1998)

Homozygous third larval instar have variably reduced central nervous systems.

(Raftery et al., 1995)

Lethality occurs during larval and pupal stages.

(Raftery, 1995.4.6)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Mad^D24, Med⁴ has visible | dominant phenotype

(Chen et al., 1998)

Mad^D3, Med⁴ has visible | dominant phenotype

(Chen et al., 1998)

E(tkv)D1^D1, Med⁴ has visible | dominant phenotype

(Chen et al., 1998)

Mad^D15, Med⁴ has visible | dominant phenotype

(Chen et al., 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

Med⁴ is an enhancer of phenotype of dpp^hr4

(Raftery et al., 1995)

Suppressor of

Statement

Reference

Med⁴/Med² is a suppressor of embryonic midgut constriction 1 phenotype of Scer\GAL4^how-24B, dpp^UAS.cSa

(Wisotzkey et al., 1998)

Med⁴/Med² is a suppressor of embryonic midgut constriction 3 phenotype of Scer\GAL4^how-24B, dpp^UAS.cSa

(Wisotzkey et al., 1998)

Other

Statement

Reference

Med⁴, dpp^hr4/dpp[+] has cephalopharyngeal skeleton phenotype

(Raftery et al., 1995)

Med⁴/Med[+], dpp^hr4 has cephalopharyngeal skeleton phenotype

(Raftery et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

No interaction with tkv⁶, tkv^D17, E(tkv)D2^D2, Mad^D14, Mad^D16, gbb^D4, gbb^D8, gbb^D20, put^D13 or put^D18 is seen in double heterozygous flies. Double heterozygotes with E(tkv)D1^D1, Mad^D3, Mad^D15 or Mad^D24 may show imaginal disc development defects.

(Chen et al., 1998)

The combination Med²/Med⁴ usually restores the first and third midgut constrictions in embryos expressing dpp^Scer\UAS.cSa under the control of Scer\GAL4^how-24B.

(Wisotzkey et al., 1998)

Maternal lethal interaction with dpp^hr4 is due to a loss of dorsal-most fates in the embryos, demonstrated by loss of amnioserosa cells. dpp^hr4/dpp⁺;Med⁴/Med⁺ embryos have a partially involuted head skeleton. Embryos exhibits a 'tail up' phenotype, the posterior most structures are pointed more vertically and there is more curvature to the abdominal segments.

(Raftery et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Med¹³

(Hudson et al., 1998)

Med¹⁵

(Hudson et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Med⁴

(Christoforou et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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