FlyBase Allele Report: Dmel\Pka-C1[k11302]

General Information

Symbol

Dmel\Pka-C1^k11302

Species

D. melanogaster

Name

FlyBase ID

FBal0045003

Feature type

allele

Associated gene

Dmel\Pka-C1

Associated Insertion(s)

P{lacW}Pka-C1^k11302

Carried in Construct

Also Known As

pkA^P113/2

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Lepage et al., 1995)

Progenitor genotype

Associated Insertion(s)

P{lacW}Pka-C1^k11302

Cytology

Description

Nested insertion of two P{lacW} elements (one incomplete) located 15bp upstream from the transcription start site.

(Lepage et al., 1995)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:9,699,298..9,699,298 [-]

(Lepage et al., 1995, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Lepage et al., 1995)

visible | recessive

(Lepage et al., 1995)

Phenotype Manifest In

leg

(Lepage et al., 1995)

scutum

(Lepage et al., 1995)

wing blade anterior compartment

(Lepage et al., 1995)

Detailed Description

Statement

Reference

Homozygotes exhibit bifurcation of the anterior wing compartment. The supernumerary wing contains two anterior wing margins and two first veins. Axis bifurcation of the notum and legs are seen at a low frequency. Phenotype is more severe in hemizygotes.

(Lepage et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Pka-C1^k11302/Pka-C1^k08918 has phenotype, non-suppressible by fu^J

(Sanchez-Herrero et al., 1996)

NOT Suppressor of

Statement

Reference

Pka-C1^k11302/Pka-C1^k08918 is a non-suppressor of phenotype of fu^J

(Sanchez-Herrero et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

fu^J; Pka-C1^k11302/Pka-C1^k08918 flies show no suppression of either the Pka-C1^k11302/Pka-C1^k08918 or fu^J mutant phenotypes.

(Sanchez-Herrero et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

This allele was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was discarded from the gene disruption project prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Spradling (spradling@mail1.ciwemb.edu).

Mutant phenotype has been reverted by excision of the P-element.

(Lepage et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Pka-C1^k11302

Pka^P113/2

(Grimm and Pflugfelder, 1996)

pkA^P113/2

(Sanchez-Herrero et al., 1996)

pka^P113/2

(Lepage et al., 1995)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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