FlyBase Allele Report: Dmel\Pka-C1[k08918]

General Information

Symbol

Dmel\Pka-C1^k08918

Species

D. melanogaster

Name

FlyBase ID

FBal0042708

Feature type

allele

Associated gene

Dmel\Pka-C1

Associated Insertion(s)

P{lacW}Pka-C1^k08918

Carried in Construct

Also Known As

pka^P89/18, pka^89/18

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Lecuit and Cohen, 1997)

Mutagen

P-element activity

(Lepage et al., 1995, Strutt et al., 1995)

Progenitor genotype

Associated Insertion(s)

P{lacW}Pka-C1^k08918

Cytology

Description

P{lacW} insertion within the first intron.

(Lepage et al., 1995, Strutt et al., 1995)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:9,698,578..9,698,585 [-]

(Cho et al., 1999, Lepage et al., 1995, Strutt et al., 1995, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Lepage et al., 1995, Strutt et al., 1995)

visible

(Strutt et al., 1995)

Phenotype Manifest In

eye

(Strutt et al., 1995)

eye-antennal disc

(Wiersdorff et al., 1996)

leg anterior compartment

(Lepage et al., 1995)

wing blade anterior compartment

(Lepage et al., 1995)

Detailed Description

Statement

Reference

Double mutant clones of Mad^1-2 with Pka-C1^k08918 located in posterior locations show a phenotype similar to Mad single mutant clones, except that they are more frequently associated with overgrowth. Double mutant clones in more anterior positions show a novel phenotype, and are always associated with overgrowth with no ectopic furrow or photoreceptor differentiation. These clones give rise to head cuticle in adult flies.

(Wiersdorff et al., 1996)

Homozygous mutant clones that cross the dorsal ventral compartment boundary cause bifurcations. Clones present at the anterior posterior wing boundary or on the dorsal or ventral surface of the posterior wing compartment have no phenotype. Clones present in the anterior compartment of the male foreleg cause bifurcation.

(Lepage et al., 1995)

Homozygous mutant clones in the compound eye demonstrate non-autonomous eye roughening. Bulging of the eye surface is commonly seen in anterior positioned clones, clones in the posterior region are often smooth.

(Strutt et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Pka-C1^k11302/Pka-C1^k08918 has phenotype, non-suppressible by fu^J

(Sanchez-Herrero et al., 1996)

Suppressor of

Statement

Reference

Pka-C1[+]/Pka-C1^k08918 is a suppressor of eye phenotype of hh^ts2

(Strutt et al., 1995)

NOT Suppressor of

Statement

Reference

Pka-C1^k11302/Pka-C1^k08918 is a non-suppressor of phenotype of fu^J

(Sanchez-Herrero et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

fu^J; Pka-C1^k11302/Pka-C1^k08918 flies show no suppression of either the Pka-C1^k11302/Pka-C1^k08918 or fu^J mutant phenotypes.

(Sanchez-Herrero et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Pka-C1^s4402

(BDGP Project Members, 1994-1999)

Pka-C1⁰¹²⁷²

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

I. Kiss.

Comments

Complements: hoip^k07104.

(BDGP Project Members, 1994-1999)

Mutant phenotype has been reverted by excision of the P-element.

(Lepage et al., 1995)

Reversion of the mutant phenotype by P-element excision.

(Strutt et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

PKA^89/18

(Wiersdorff et al., 1996)

Pka-C1^k08918

pkA^P89/18

(Sanchez-Herrero et al., 1996)

pka-C1^89/18

(Strutt et al., 1995)

pka^89/18

(Lecuit and Cohen, 1997)

pka^P89/18

(Cho et al., 1999, Lepage et al., 1995)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

Open Close