FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\γTub37C11
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General Information
Symbol
Dmel\γTub37C11
Species
D. melanogaster
Name
FlyBase ID
FBal0045690
Feature type
allele
Associated gene
Dmel\γTub37C
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Endow and Komma, 1998)
Progenitor genotype
Cytology
Description

Carries an E117K amino acid substitution.

(Hallen et al., 2008)

Amino acid replacement: E117K.

(Hallen et al., 2008, Wilson, 1999.12.22)

Nucleotide substitution: G349A. Amino acid replacement: E116R.

(Wilson and Borisy, 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:19,185,127..19,185,127 [-]
Nucleotide change:

G19185127A

Reported nucleotide change:

G349A|FBrf0103392

Amino acid change:

E117K | gammaTub37C-PA; E117K | gammaTub37C-PB

Reported amino acid change:

E117K|FBrf0122632

Reported amino acid change:

E116R|FBrf0103392

(Wilson, 1999.12.22, Wilson and Borisy, 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      γTub37C11/Df(2L)VA23 females produce many eggs, but the eggs fail to hatch.

      (Hallen et al., 2008)

      Centrosome-like structures are detected in more than 75% of embryos derived from γTub37C11/Df(2L)TE37C-7 females.

      (Wilson and Borisy, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      γTub37C11 is an enhancer of abnormal meiotic cell cycle phenotype of ncdD

      (Endow and Komma, 1998)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Strongly dominantly enhances the increased meiotic nondisjunction seen in homozygous ncdD females. γTub37C11/+ ; ncdD/+ females show an enhanced frequency of nondisjunctional offspring compared to ncdD/+ females.

      (Endow and Komma, 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      γTub37C11 is rescued by γTub37Cncd.GFP(S65T)

      (Hallen et al., 2008)
      Comments

      γTub37Cncd.T:Avic\GFP-S65T rescues the female sterility of γTub37C11/Df(2L)VA23 flies.

      (Hallen et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      fs(2)PL10
      fs(2)TW111
      fs(2)TW1APL10
      (Endow and Komma, 1998)
      γTub37C APL10
      (Hallen et al., 2008)
      γTub37C11
      γTub37CDPL10
      (Wilson, 1999.12.22, Wilson and Borisy, 1998)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)