sub¹⁷⁹⁴ show allele specific interactions with alleles of ncd. sub¹⁷⁹⁴/+, ncd^D/+ transheterozygotes show a high frequency of non-disjunction, whereas either mutation alone is completely recessive. sub¹⁷⁹⁴/+, ncd¹/+ transheterozygotes do not show this effect. Stage 14 oocytes of sub¹⁷⁹⁴/+, ncd^D/+ show a defect in spindle pole formation - most often spindles are either monopolar or tripolar, karyosome may be split, spindles broken or misshapen such that they fray, or do not taper at the poles.

ncd¹/ncd^D female X and 4th chromosome nondisjunction is dominantly suppressed by lwr⁰⁵⁴⁸⁶.

The increased meiotic nondisjunction seen in homozygous females is strongly dominantly enhanced by γTub37C¹³ or γTub37C¹¹, while γTub37C¹² causes only a small increase in nondisjunction. The viability of eggs laid by ncd^D females is also dominantly reduced by γTub37C¹³. γTub37C¹¹/+ ; ncd^D/+ females show an enhanced frequency of nondisjunctional offspring compared to ncd^D/+ females. ncd^D females heterozygous for Df(2L)VA23 show reduced embryo viability but no significant difference in meiotic or mitotic chromosome distribution compared to ncd^D females.

The ncd^D phenotype is dominantly enhanced by αTub67C¹ and αTub67C³; ncd^D/ncd^D αTub67C¹ flies have a X chromosome nondisjunction frequency of 0.194 and ncd^D/ncd^D αTub67C³ flies have a X chromosome nondisjunction frequency of 0.149. Zygotic loss of the X chromosome in ncd^D/ncd^D females is also dominantly enhanced by αTub67C¹ and αTub67C³.This enhancement by αTub67C¹ and αTub67C³ is not seen in ncd^D heterozygotes. αTub67C² does not significantly alter the frequencies of nondisjunction and zygotic loss of the X chromosome in ncd^D/ncd^D flies. ncd^D/ncd^D enhances the production of exceptional androgenetic females by αTub67C¹ and αTub67C³ heterozygotes but not by αTub67C² heterozygotes. Meiotic nondisjunction is significantly decreased in ncd^D αTub67C² double heterozygous females compared to αTub67C² single heterozygous females. Homozygous and heterozygous females show a significant increase in meiotic and zygotic chromosome loss if also heterozygous for Df(3L)AC1. Homozygotes also heterozygous for Df(3L)AC1 show a decrease in nondisjunction. Homozygous females show no significant difference in meiotic nondisjunction and zygotic chromosome loss if also heterozygous for Df(3R)Scx2. αTub67C³/+ ncd^D/ncd^D embryos have both a male and female pronucleus, but have defects in pronuclear conjugation or fusion and show delayed meiotic progression.

Patroclinous females are produced at a low frequency by heterozygous αTub67C³ females carrying ncd^D. The females arise by fusion of haploid cleavage nuclei or failure of newly replicated haploid chromosomes to segregate.