FB2026_02 , released June 18, 2026
Allele: Dmel\γTub37C13
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General Information
Symbol
Dmel\γTub37C13
Species
D. melanogaster
Name
FlyBase ID
FBal0045692
Feature type
allele
Associated gene
Dmel\γTub37C
Associated Insertion(s)
Carried in Construct
Also Known As
fs(2)TW1HL2
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Endow and Komma, 1998)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G610A. Amino acid replacement: V204M.

(Wilson and Borisy, 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:19,184,866..19,184,866 [-]
Nucleotide change:

G19184866A

Reported nucleotide change:

G610A|FBrf0103392

Amino acid change:

V204M | gammaTub37C-PA; V204M | gammaTub37C-PB

Reported amino acid change:

V204M|FBrf0103392

(Wilson and Borisy, 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Centrosome-like structures are detected in more than 75% of embryos derived from γTub37C13/Df(2L)TE37C-7 females.

      (Wilson and Borisy, 1998)

      The chromosome arrangement at metaphase-I arrest females is severely disrupted, the chromosomes are arranged randomly. 30% of meiotic figures are abnormal in oocytes. Defect is due to failure to organise the meiotic spindle. Cleavage divisions are also impaired, embryos display abnormal patterns of chromatin distribution, microtubule organisation is also extremely abnormal. Embryonic development is arrested before the syncytial blastoderm stage. Defects are due to a requirement for γTub37C function during embryogenesis. Females can be rescued to fertility by γTub37C+t7.2.

      (Tavosanis et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Dominantly enhances the inviability of eggs laid by ncd1 or ncd2 females. Strongly dominantly enhances the increased meiotic nondisjunction seen in homozygous ncdD females. Also dominantly reduces viability of eggs laid by ncdD females.

      (Endow and Komma, 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      γTub37C13 is rescued by γTub37C+t7.2

      (Tavosanis et al., 1997)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      fs(2)HL2
      fs(2)TW113
      fs(2)TW1HL2
      (Endow and Komma, 1998, Tavosanis et al., 1997)
      γTub37C13
      γTub37CDHL2
      (Wilson and Borisy, 1998)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)