FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ncd2
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General Information
Symbol
Dmel\ncd2
Species
D. melanogaster
Name
FlyBase ID
FBal0012911
Feature type
allele
Associated gene
Dmel\ncd
Associated Insertion(s)
Carried in Construct
Also Known As
ncd
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Komma and Endow, 1997, Hatsumi and Endow, 1992)
Mutagen
ethyl methanesulfonate
(Endow and Komma, 1997, Hatsumi and Endow, 1992, Yamamoto et al., 1989)
Progenitor genotype
Cytology
Description

Amino acid replacement: G446R. Amino acid replacement: A566S. Amino acid replacement: G696A. G446R change affects a highly conserved glycine residue in the ATP-binding region, A566S is a conservative amino acid change and G696A is outside the motor domain.

(Endow and Komma, 1997)

no 2.6 kb deletion

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:29,805,173..29,805,173 [-]
Nucleotide change:

G29805173C

Amino acid change:

G446R | ncd-PA; G446R | ncd-PB

Reported amino acid change:

G446R

Comment:

site of nucleic acid difference inferred by FlyBase based on stated amino acid change

(Endow and Komma, 1997)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      meiosis & nuclear chromosome & oocyte

      (Hatsumi and Endow, 1992)
      Detailed Description
      Statement
      Reference

      Most of the meiotic exceptions result from chromosome loss. Frayed and monopolar spindles are frequently observed.

      (Sekelsky et al., 1999)

      Approximately 90% of eggs laid by homozygous females fail to hatch.

      (Endow and Komma, 1998)

      Homozygous females show increased chromosome nondisjunction and loss compared to wild-type. Embryos derived from homozygous females have reduced viability. The chromosome missegregation phenotype is fully rescued in heterozygous females but embryo viability is only partially rescued.

      (Endow and Komma, 1997)

      Homozygous oocytes show abnormal chromosome behaviour in meiosis. Bivalents segregating in different directions are seen in anaphase I.

      (Hatsumi and Endow, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Other
      Statement
      Reference

      αTub67C3, ncd2 has female sterile phenotype

      (Komma and Endow, 1997)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The ncd2 inviability is dominantly enhanced by γTub37C13 or γTub37C12; ncd2 females heterozygous for γTub37C13 or γTub37C12 lay eggs but more than 99% fail to hatch.

      (Endow and Komma, 1998)

      ncd2/ncd2 αTub67C3 females are sterile.

      (Komma and Endow, 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      ncdP39

      (Sekelsky et al., 1999)

      ncd8

      (Yamamoto et al., 1989)

      ncd7

      (Yamamoto et al., 1989)

      ncd6

      (Yamamoto et al., 1989)

      ncd5

      (Yamamoto et al., 1989)
      Partially rescued by

      ncd2 is partially rescued by ncd2.GFP(S65T)

      (Endow and Komma, 1997)
      Comments

      ncd2/ncd2 females carrying two copies of ncd2.T:Avic\GFP-S65T have poor fertility, high egg inviability and elevated chromosome missegregation. ncd2/+ females carrying one copy of ncd2.T:Avic\GFP-S65T are completely rescued for chromosome segregation but partially rescued for embryo viability.

      (Endow and Komma, 1997)

      recovered as ca+

      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Mutant does not affect ca function.

      (Yamamoto et al., 1989)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ncd
      (Sekelsky et al., 1999, Hatsumi and Endow, 1992, Hatsumi and Endow, 1992, Yamamoto et al., 1989)
      ncd2
      Name Synonyms
      Secondary FlyBase IDs
        References (9)