FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\αTub67C2
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General Information
Symbol
Dmel\αTub67C2
Species
D. melanogaster
Name
FlyBase ID
FBal0000009
Feature type
allele
Associated gene
Dmel\αTub67C
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Matthews et al., 1993)
Mutagen
ethyl methanesulfonate
(Matthews et al., 1993)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      αTub67C1/αTub67C2 females show severe defects in bipolar spindle formation in the oocyte.

      (Jang et al., 2005)

      X/FM7a; αTub67C2/+ females show elevated levels of X chromosome nondisjunction.

      (Matthies et al., 1999)

      Eggs derived from females transheterozygous for αTub67Cunspecified and αTub67C2 have abnormal gonomeric spindles. Abnormal ectopic cleavage spindles form, the abnormality becoming more severe with time.

      (Mathe et al., 1998)

      Embryos derived from homozygous females have a single large polar body with greater than 4 haploid sets of chromosomes.

      (Komma and Endow, 1997)

      αTub67C3/αTub67C2 : females produce patroclinous daughters at low frequency; these females arise by fusion of haploid cleavage nuclei or failure of newly replicated haploid chromosomes to segregate.

      (Komma and Endow, 1995)

      No eggs from hemizygous females hatch. Many are apparently unfertilized, though insemination occurs. Paternal genotype has no effect on viability of progeny. 2% of eggs from homozygous females develop to adults. Majority of eggs had 3 or fewer nuclei. This allele also shows a dominant reduction in female fertility.

      (Matthews et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      αTub67C2 has female sterile | dominant phenotype, suppressible by swaunspecified

      (Pokrywka et al., 2004)
      Other
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      αTub67C2 has phenotype, suppressible by nodunspecified

      (Matthies et al., 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      ncdD/ncdD does not enhance the production of exceptional androgenetic females by αTub67C2 heterozygotes. αTub67C2 does not significantly alter the frequencies of nondisjunction and zygotic loss of the X chromosome in ncdD/ncdD flies. Meiotic nondisjunction is significantly decreased in ncdD αTub67C2 double heterozygous females compared to αTub67C2 single heterozygous females.

      (Komma and Endow, 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Rees.

      Comments
      Comments

      Based on average degree of development of eggs of the hemizygous mutant genotype the alleles can be ranked, from most to least severe, in the order αTub67C2 < αTub67C4 < αTub67C1 < αTub67C3. Based on the semidominant phenotypes the rank order is αTub67C3 < αTub67C1 = αTub67C2 = αTub67C4.

      (Matthews et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      α-Tub67C2
      (Jang et al., 2005)
      αTub67C2
      (Fahmy et al., 2014)
      αtub67C2
      (Matthies et al., 1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)