FlyBase Allele Report: Dmel\hrg[P1]

General Information

Symbol

Dmel\hrg^P1

Species

D. melanogaster

Name

FlyBase ID

FBal0045900

Feature type

allele

Associated gene

Dmel\hrg

Associated Insertion(s)

P{UAS-RBZ.ftz-F1}hrg^P1

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Murata et al., 1996, Murata et al., 1996)

Progenitor genotype

Associated Insertion(s)

P{UAS-RBZ.ftz-F1}hrg^P1

Cytology

Description

Insertion 615bp upstream of the ATG codon.

(Murata et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:19,668,863..19,668,863 [-]

(Juge et al., 2002, Murata et al., 2001, Murata et al., 1996, Murata et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Murata et al., 1996)

viable

(Murata et al., 1996)

visible

(Murata et al., 2001)

visible | recessive

(Murata et al., 1996, Murata et al., 1996)

Phenotype Manifest In

wing

(Juge et al., 2002, Murata et al., 2001, Murata et al., 1996, Murata et al., 1996)

wing (with hrg^PAP12)

(Juge et al., 2002)

Detailed Description

Statement

Reference

Mutants have notched wings. hrg^PAP12,hrg^P1 animals have a notched wing phenotype.

(Juge et al., 2002)

Mutants have a notched wing phenotype.

(Murata et al., 2001)

Wings are scalloped.

(Murata et al., 1996)

Homozygotes have notched wing margins. The notches are usually seen between the second and fifth wing veins, although their number and location varies.

(Murata et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

hrg^P1 has wing phenotype, enhanceable by Ser¹

(Murata et al., 1996)

hrg^P1 has wing phenotype, enhanceable by N^55e11

(Murata et al., 1996)

hrg^P1 has wing phenotype, enhanceable by dx^unspecified

(Murata et al., 1996)

Suppressed by

Statement

Reference

hrg^P1 has wing vein phenotype, suppressible by H^unspecified

(Murata et al., 1996)

Enhancer of

Statement

Reference

hrg^P1 is an enhancer of wing phenotype of Ser¹

(Murata et al., 1996)

hrg^P1 is an enhancer of wing phenotype of N^55e11

(Murata et al., 1996)

hrg^P1 is an enhancer of wing vein phenotype of N^55e11

(Murata et al., 1996)

hrg^P1 is an enhancer of wing vein phenotype of dx^unspecified

(Murata et al., 1996)

hrg^P1 is an enhancer of wing vein L2 phenotype of dx^unspecified

(Murata et al., 1996)

hrg^P1 is an enhancer of wing vein L3 phenotype of dx^unspecified

(Murata et al., 1996)

hrg^P1 is an enhancer of wing vein L5 phenotype of dx^unspecified

(Murata et al., 1996)

Suppressor of

Statement

Reference

hrg^P1 is a suppressor of wing vein phenotype of H^unspecified

(Murata et al., 1996)

Other

Statement

Reference

Ser¹, hrg^P1 has wing vein L1 phenotype

(Murata et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

hrg^P1/hrg^P1; Ser^D/+ flies show synergistic enhancement of the notched wing phenotype, with deeper wing notching than is seen in either hrg^P1/hrg^P1 or Ser^D/+ single mutant flies, and loss of most of the first wing vein. The notching is also not restricted to sites between the second and fifth wing vein. Wing phenotypes are synergistically enhanced in dx^unspecified/dx^unspecified; hrg^P1/hrg^P1 flies, with enhancement of vein confluences seen mainly in the second, third and fifth veins. Wing notching is also more extreme than in hrg^P1/hrg^P1 single mutant flies. The wing phenotypes of hrg^P1 and H^unspecified single mutants are suppressed in hrg^P1; H^unspecified/+ flies, although the thorax bristle phenotype of hrg^P1; H^unspecified/+ flies is indistinguishable from that of H^unspecified single mutant flies. The wing phenotype is synergistically enhanced in N^55e11/+ ; hrg^P1/hrg^P1 flies. hrg^P1/hrg^P1; Df(3R)Dl-FX3/+ flies have an additive phenotype; a confluence and 'delta' phenotype the same as the Df(3R)Dl-FX3 single mutant, and a wing notching phenotype the same as the hrg^P1/hrg^P1 single mutant.