FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\inv30
Open Close
General Information
Symbol
Dmel\inv30
Species
D. melanogaster
Name
FlyBase ID
FBal0045908
Feature type
allele
Associated gene
Dmel\inv
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Gustavson et al., 1996, Tabata et al., 1995)

loss of function allele

(Bhat and Schedl, 1997)
Mutagen
Delta2-3 transposase
(Gustavson et al., 1996)
Progenitor genotype
invXba21
(Gustavson et al., 1996)
Cytology
Description

Small deficiency removing the first exon.

(Bhat and Schedl, 1997)

Intragenic deletion removing most of the inv transcription unit. The portion of the gene encoding the homeodomain is left intact.

(Gustavson et al., 1996)

Intragenic deletion removing approximately 27kb of the inv transcription unit, including the transcription start site, the first two exons and most of the second intron.

(Tabata et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Gaps are seen in the posterior of the hindgut boundary cell rows in mutant embryos.

      (Iwaki and Lengyel, 2002)

      The development of the border cells of the hindgut (which normally form an anterior and posterior ring at the ends of the hindgut and bilateral strands that connect the two rings) is not affected in mutant embryos.

      (Takashima and Murakami, 2001)

      Homozygous embryos do not show duplications of the RP2 neuron.

      (Bhat and Schedl, 1997)

      Survives without abnormality over Df(2R)en-SFX31, except for slight defects on the anterior crossvein.

      (Gustavson et al., 1996)

      Adult flies are normal in appearance.

      (Tabata et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      91% of Df(2R)enΔ530/en9 inv30 wings exhibit split veins in the posterior compartment.

      (DeVido et al., 2008)

      Approximately 34% of fra1/inv30 double mutants exhibit defects in axonal pathfinding. Stage 15 embryos display dramatic defects in ventral nerve cord architecture, with the posterior commissures missing or fused with the anterior commissures, and longitudinal tracts thinner. Approximately 87% of the segments are affected in these embryos.

      Approximately 15% of fra1/inv30 double mutants are adult lethal.

      (Joly et al., 2007)

      In combination with en9.6, defects are more extreme than for simple en mutant, en8. Clones in the wing of the double mutant inv30, en9.6 are associated with anterior transformations and mirror image duplications, similar in character to those caused by clones of Df(2R)enE.

      (Tabata et al., 1995)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Df(2R)inv30
      (Gustavson et al., 1996)
      inv30
      (Bailetti et al., 2019, DeVido et al., 2008, Joly et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)