FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mod(mdg4)B2
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General Information
Symbol
Dmel\mod(mdg4)B2
Species
D. melanogaster
Name
FlyBase ID
FBal0046117
Feature type
allele
Associated gene
Dmel\mod(mdg4)
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gerasimova et al., 1995)
Progenitor genotype
P{lacW}tin142
(Gerasimova et al., 1995)
Caused by aberration
Df(3R)mod(mdg4)B2
Cytology
Description

Deletion with a breakpoint within the variable region exons of mod(mdg4). The deletion extends proximally from the breakpoint in mod(mdg4).

(Soltani-Bejnood et al., 2007)

Deletion obtained by excision of a P-element located in the adjacent gene, tin.

(Gerasimova et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In the presence of su(Hw)MC the In(1)wm4 phenotype is no longer enhanced and the eye phenotype returns to wild type.

      (Gerasimova et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      mod(mdg4)Z3-3401

      (Soltani-Bejnood et al., 2007)
      Partially complements

      mod(mdg4)Z3-5578

      (Soltani-Bejnood et al., 2007)

      mod(mdg4)Z3-3298

      (Soltani-Bejnood et al., 2007)
      Comments

      The semi-lethal phenotype of mod(mdg4)B2 is fully complemented by mod(mdg4)Z3-5578 and mod(mdg4)Z3-3298, but mod(mdg4)B2 fails to complement these alleles with respect to X-Y chromosome nondisjunction in male meiosis - the transheterozygotes show a high level of X-Y nondisjunction (frequency is indicated in parentheses after each allele); mod(mdg4)Z3-5578 (37.3%) and mod(mdg4)Z3-3298 (40.2%).

      The lethal phenotype of mod(mdg4)B2 is fully complemented by mod(mdg4)Z3-3401, and mod(mdg4)B2 fully complements mod(mdg4)Z3-3401 with respect to X-Y chromosome nondisjunction in male meiosis - transheterozygotes show no X-Y nondisjunction.

      (Soltani-Bejnood et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      B2
      (Soltani-Bejnood et al., 2007)
      mod(mdg4)B2
      Name Synonyms
      Secondary FlyBase IDs
        References (2)