Open Close
General Information
Symbol
Dmel\ninaERH27
Species
D. melanogaster
Name
FlyBase ID
FBal0046181
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Nucleotide change:

    G19887194A

    Amino acid change:

    C200Y | ninaE-PA

    Reported amino acid change:
    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Amino acid replacement: C200Y.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    ninaERH27 flies start to lose photoreceptor cells after 25 days of 12-h light/12-h dark cycling.

    Ommatidia, after light-rearing for 8 weeks, exhibit small cell bodies for R1-R6 and the rhabdomere membranes are reduced and disorganised. Cells show the typical features of apoptosis: cytoplasmic condensation, nuclear chromatin condensation and relatively normal looking mitochondria.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    NOT suppressed by
    Statement
    Reference
    Other
    Phenotype Manifest In
    NOT Enhanced by
    Suppressor of
    Statement
    Reference

    ninaERH27 is a suppressor of phenotype of norpA36

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Overexpression of Tsc1Scer\UAS.cGa or gigScer\UAS.cTa under the control of Scer\GAL4GMR.PU does not attenuate photoreceptor cell death in ninaERH27 flies and even has converse effects.

    Direct induction of autophagy by expression of Atg1ninaE.T:Hsap\MYC does not suppress cell death caused by the dominant ninaERH27 mutation.

    Light-induced retinal degeneration is blocked by expression of BacA\p35GMR.PH : photoreceptor cells and organelles are indistinguishable from wild-type. The 'walking optomotor response' for ninaERH27/BacA\p35GMR.PH flies is normal.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (10)