FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ninaERH27
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General Information
Symbol
Dmel\ninaERH27
Species
D. melanogaster
Name
FlyBase ID
FBal0046181
Feature type
allele
Associated gene
Dmel\ninaE
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: C200Y.

    (Davidson and Steller, 1996, Kurada and O'Tousa, 1995)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:19,887,194..19,887,194 [-]
    Nucleotide change:

    G19887194A

    Amino acid change:

    C200Y | ninaE-PA

    Reported amino acid change:

    C200Y|FBrf0080181

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Kurada and O'Tousa, 1995)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        ninaERH27 flies start to lose photoreceptor cells after 25 days of 12-h light/12-h dark cycling.

        (Wang et al., 2009)

        Ommatidia, after light-rearing for 8 weeks, exhibit small cell bodies for R1-R6 and the rhabdomere membranes are reduced and disorganised. Cells show the typical features of apoptosis: cytoplasmic condensation, nuclear chromatin condensation and relatively normal looking mitochondria.

        (Davidson and Steller, 1998)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT suppressed by
        Statement
        Reference

        ninaERH27 has increased cell death phenotype, non-suppressible by Atg1ninaE.Tag:MYC

        (Wang et al., 2009)
        Other
        Phenotype Manifest In
        NOT Enhanced by
        Statement
        Reference

        ninaERH27 has photoreceptor neuron phenotype, non-enhanceable by Tsc1UAS.cGa/Scer\GAL4GMR.PU

        (Wang et al., 2009)

        ninaERH27 has photoreceptor neuron phenotype, non-enhanceable by gigUAS.cTa/Scer\GAL4GMR.PU

        (Wang et al., 2009)
        Suppressor of
        Statement
        Reference

        ninaERH27 is a suppressor of phenotype of norpAP24

        (Kurada and O'Tousa, 1995)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Overexpression of Tsc1Scer\UAS.cGa or gigScer\UAS.cTa under the control of Scer\GAL4GMR.PU does not attenuate photoreceptor cell death in ninaERH27 flies and even has converse effects.

        Direct induction of autophagy by expression of Atg1ninaE.T:Hsap\MYC does not suppress cell death caused by the dominant ninaERH27 mutation.

        (Wang et al., 2009)

        Light-induced retinal degeneration is blocked by expression of BacA\p35GMR.PH : photoreceptor cells and organelles are indistinguishable from wild-type. The 'walking optomotor response' for ninaERH27/BacA\p35GMR.PH flies is normal.

        (Davidson and Steller, 1998)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        C200Y
        (Bentrop, 1998)
        NinaERH27
        (Wang et al., 2009)
        ninaERH27
        (Ryoo et al., 2007)
        Name Synonyms
        Secondary FlyBase IDs
          References (10)