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General Information
Symbol
Dmel\Tsc1UAS.cGa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Gao
FlyBase ID
FBal0123963
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-TSC1
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS sequences drive expression of the Tsc1 cDNA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
 

Co-expression (single expression of either construct untested) of Tsc1Scer\UAS.cGa and gigScer\UAS.cTa ameliorates neurodegenerative disease modeled by trpP365.

Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Tsc1Scer\UAS.cGa under the control of Scer\GAL4da.G32 at 29oC results in an increase in mean life span of 14% compared to control flies.

Expression of Tsc1Scer\UAS.cGa when driven by Scer\GAL4Bx-MS1096 causes no visible phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of Tsc1Scer\UAS.cGa and gigScer\UAS.cTa driven by Scer\GAL4GMR.PF (to induce autophagy) partially suppresses age-dependent retinal degeneration (loss of rhabdomeres from photoreceptors) in trpP365/+ flies.

norpA36 -mediated photoreceptor degeneration is significantly suppressed by overexpression of Tsc1Scer\UAS.cGa under the control of Scer\GAL4GMR.PU.

Overexpression of Tsc1Scer\UAS.cGa under the control of Scer\GAL4GMR.PU does not attenuate photoreceptor cell death in ninaERH27 flies and even has converse effects.

Expression of Tsc1Scer\UAS.cGa and gigScer\UAS.cGa under the control of Scer\GAL4arm.PS rescues lethality in 40% of Pten3/Df(2L)flp170B animals.

Co-expression of gigScer\UAS.cGa and Tsc1Scer\UAS.cGa when driven by Scer\GAL4Bx-MS1096 leads to a dramatic reduction in wing size. There is a 72% reduction in wing size and a 65% reduction in cell size.

Xenogenetic Interactions
Statement
Reference

Overexpression of Tsc1Scer\UAS.cGa under the control of Scer\GAL4GMR.PU largely suppresses neural degeneration caused by expression of Hsap\HDGMR.Q120.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Tsc1Scer\UAS.cGa
Tsc1UAS.cGa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Gao
Secondary FlyBase IDs
    References (8)