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Citation
Kapahi, P., Zid, B.M., Harper, T., Koslover, D., Sapin, V., Benzer, S. (2004). Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.  Curr. Biol. 14(10): 885--890.
FlyBase ID
FBrf0179269
Publication Type
Research paper
Abstract

In many species, reducing nutrient intake without causing malnutrition extends lifespan. Like DR (dietary restriction), modulation of genes in the insulin-signaling pathway, known to alter nutrient sensing, has been shown to extend lifespan in various species. In Drosophila, the target of rapamycin (TOR) and the insulin pathways have emerged as major regulators of growth and size. Hence we examined the role of TOR pathway genes in regulating lifespan by using Drosophila. We show that inhibition of TOR signaling pathway by alteration of the expression of genes in this nutrient-sensing pathway, which is conserved from yeast to human, extends lifespan in a manner that may overlap with known effects of dietary restriction on longevity. In Drosophila, TSC1 and TSC2 (tuberous sclerosis complex genes 1 and 2) act together to inhibit TOR (target of rapamycin), which mediates a signaling pathway that couples amino acid availability to S6 kinase, translation initiation, and growth. We find that overexpression of dTsc1, dTsc2, or dominant-negative forms of dTOR or dS6K all cause lifespan extension. Modulation of expression in the fat is sufficient for the lifespan-extension effects. The lifespan extensions are dependent on nutritional condition, suggesting a possible link between the TOR pathway and dietary restriction.

PubMed ID
PubMed Central ID
PMC2754830 (PMC) (EuropePMC)
Related Publication(s)
Erratum

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.
Kapahi et al., 2004, Curr. Biol. 14: 1789 [FBrf0185644]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Biol.
    Title
    Current Biology
    Publication Year
    1991-
    ISBN/ISSN
    0960-9822
    Data From Reference