FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\poe03420
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General Information
Symbol
Dmel\poe03420
Species
D. melanogaster
Name
FlyBase ID
FBal0046335
Feature type
allele
Associated gene
Dmel\poe
Associated Insertion(s)
P{PZ}poe03420
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Soehnge et al., 1995, Castrillon et al., 1993)
Delta2-3 transposase
(Riesgo-Escovar et al., 1992)
Progenitor genotype
Associated Insertion(s)
P{PZ}poe03420
Cytology
Description

The P{PZ} is inserted 260bp downstream of the putative poe TATA box.

(Yager et al., 2001)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes exhibit a 'pushover' phenotype and defects in flight. Mutant larvae exhibit normal synaptic transmission at the neuromuscular junction.

      (Richards et al., 1996)

      Postmeiotic differentiation defect.

      (Castrillon et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially complements

      poe1

      (Richards, 1996.4.29)
      Fails to complement

      poeunspecified

      (Yager et al., 2001)

      poeP21

      (Sekelsky et al., 1999)
      Comments

      The poe03420 allele fails to complement the male sterility phenotype of poeunspecified.

      (Yager et al., 2001)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      This allele was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was discarded from the gene disruption project prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Spradling (spradling@mail1.ciwemb.edu).

      12 excision lines were generated of which 7 regained male fertility demonstrating the P{PZ} insertion is responsible for the male sterile phenotype.

      (Riesgo-Escovar et al., 1992)

      Complements: Hrb27C02647. Complements: Rca103300. Complements: smt304493. Complements: Hrb27CrF680. Complements: cuc06491.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (9)
      Reported As
      Symbol Synonym
      3420
      (Soehnge et al., 1995)
      Poe03420
      (Greenblatt and Spradling, 2018)
      ms(2)03420
      (Sekelsky et al., 1999)
      ms(2)27C
      (Castrillon et al., 1993)
      ms(2)27C03420
      ms(2)ry27C
      poe03420
      push03420
      push3420
      (Yager et al., 2001)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0012507
      • FBal0028429
      References (11)