FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\snG409E
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General Information
Symbol
Dmel\snG409E
Species
D. melanogaster
Name
FlyBase ID
FBal0046498
Feature type
allele
Associated gene
Dmel\sn
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Cant et al., 1998, Cant and Cooley, 1996)
Progenitor genotype
Cytology
Description

Amino acid replacement: G409E. Nucleotide substitution: G?A.

(Cant and Cooley, 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:7,985,137..7,985,137 [+]
Nucleotide change:

G7985137A

Reported nucleotide change:

G?A

Amino acid change:

G409E | sn-PA; G409E | sn-PB; G409E | sn-PE; G409E | sn-PG

Reported amino acid change:

G409E

(Cant and Cooley, 1996)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous females have a mild defect in nurse cell cytoplasm transport.

      (Cant et al., 1998)

      Bristle morphology is affected. Eggs are 75% of the size of wild type eggs. Cytoplasmic actin bundles at the nurse cell membranes appear faint and disorganized.

      (Cant and Cooley, 1996)

      Mutants have kinked bristles and are fertile, although nurse cell cytoplasmic bundles appear disorganised.

      (Cooley et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      qua9, snG409E has female sterile phenotype

      (Cant et al., 1998)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      snG409E has nurse cell phenotype, enhanceable by qua9

      (Cant et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The snG409E oogenesis phenotype is enhanced by qua9; snG409E single mutant females are fertile, but snG409E/snG409E; qua9/+ females are weakly fertile and produce approximately 20% of the amount of progeny produced by snG409E single mutant females. Females doubly homozygous for snG409E and qua9 are completely sterile. As fertility is decreased by the addition of the qua9 mutation, less nurse cell cytoplasm is transported. The fertility of qua9 single mutant homozygotes is not affected by one copy of snG409E.

      (Cant et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      snG409E
      (Andersen and Horne-Badovinac, 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)