FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\tok3
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General Information
Symbol
Dmel\tok3
Species
D. melanogaster
Name
FlyBase ID
FBal0046595
Feature type
allele
Associated gene
Dmel\tok
Associated Insertion(s)
P{wG3-4}tok3
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
PM hybrid dysgenesis
(Finelli et al., 1995)
Progenitor genotype
tokG3
(Finelli et al., 1995)
Associated Insertion(s)
P{wG3-4}tok3
Cytology
Description

Deletion extending from within the P{wG3/4} insertion into flanking tok coding sequences.

(Finelli et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      tok1/tok3 embryos exhibit longitudinal axon defects.

      (Kellermeyer et al., 2020)

      Larval lethality may be due to defects in the CNS or ring gland. Some larvae have smaller brains and imaginal discs and appear to be smaller in body size. The larvae appear to be morphologically normal but are 'sickly'. Mutant phenotype is not enhanced by removal of one copy of tok. Upto 3% progeny from heteroallelic tok combinations escape to adulthood, escapers possess wing defects (posterior crossvein is missing) and less frequently crossveins are incomplete in one or both wings.

      (Finelli et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      tok1/tok3 is a suppressor of wing disc | larval stage phenotype of PsiKK101882, Scer\GAL4Ser.PGF

      (Zaytseva et al., 2023)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Chromosome carries a second-site mutation in comm.

      (Kellermeyer et al., 2020)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      tlr13
      (Meyer and Aberle, 2006)
      tok3
      (Zaytseva et al., 2023, Macabenta et al., 2022, Kellermeyer et al., 2020, Christensen et al., 2008.4.15)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)